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Marked familial aggregation of chronic kidney disease suggests that inherited factors play a major role in nephropathy susceptibility. Molecular genetics analyses have identified a number of genes reproducibly associated with a broad range of renal phenotypes. Most associations show polygenic inheritance patterns with limited effect size. In contrast, genetic association between the apolipoprotein...
Renal involvement is a common manifestation of human immunodeficiency virus (HIV) infection and is a cause of significant morbidity and mortality, even in the age of highly active antiretroviral therapy (HAART). This review discusses the spectrum of renal pathology in the HIV-positive child and includes diseases that occur in any child regardless of the HIV status and those which are specific to the...
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