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In diesem Übersichtsartikel wird der prognostische und therapeutische Stellenwert einer Androgenrezeptorexpression beim Mammakarzinom näher beleuchtet. Durch das zunehmend bessere Verständnis der Tumorbiologie, wie auch durch die Entwicklung neuer gegen den Androgenrezeptor gerichteter Therapien, gewinnt der Androgenrezeptor in der Behandlung des Mammakarzinoms zunehmend an Bedeutung. Vor allem Enzalutamid,...
Drug resistance and especially cross-resistance are the most important problems of therapy of prostate cancer. Drug resistance mechanisms, including ligand-dependent (requiring the presence of androgens in the cell) and independent (not requiring androgens) ones, are reviewed. The mechanisms are mainly based on mutations of the androgen receptor (AR) gene, expression of aberrant constitutively active...
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