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Objectives Microelectrode recording (MER) plays an important role in target refinement in deep brain stimulation (DBS) of the subthalamic nucleus (STN) for Parkinson’s disease (PD). Traditionally, patients were operated on in the ‘off-medication’ state to allow intraoperative assessment of the patient response to direct STN stimulation. The development of intraoperative microelectrode recording (MER)...
Parkinson's disease (PD) is a progressive neurodegenerative disorder that affects ∼6 million people worldwide. Deep brain stimulation (DBS) of the subthalamic nucleus (STN) reduces motor disability and improves quality of life in patients with advanced PD who have severe levodopa-induced motor complications. Precise targeting of STN regions is a key factor for effective stimulation therapy. Dorsolateral...
In this paper we demonstrate by simulation, that the spike features apparent in low-impedance deep brain stimulation (DBS) targeting microelectrode recordings (MER) may not reflect the action potentials of individual neurons. Rather, they are more likely to be compound action potentials from a synchronized group of neurons local to the electrode. Initially we simulate the MER by combining the electric...
This study aims to evaluate the improvements of cardinal motor symptoms depending on the stimulation site relative to a standardized, reconstructed three-dimensional MRI-defined subthalamic nucleus (STN.) This retrospective, clinical study includes 22 patients with idiopathic Parkinson’s disease, who consecutively underwent bilateral subthalamic nucleus stimulation. Intraoperative microelectrode recording...
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