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Nephrogenic systemic fibrosis (NSF) is an uncommon fibrotic disorder occurring after administration of linear gadolinium contrast agents in patients with severely decreased kidney function. The underlying pathogenetic mechanism of fibrosis remains to be elucidated. Transforming growth factor β (TGF-β), a key player in the pathogenesis of fibrotic disorders, has been found to be overexpressed in NSF...
Transforming growth factor (TGF)-β regulates the function of fibroblasts, and has been shown to have a role in the pathogenesis of rheumatoid arthritis (RA) because several studies have demonstrated the presence of TGF-β in the synovial tissue and synovial fluids of RA patients. In this study, we examined the expression of TGF-β receptors in synovial fibroblasts of patients with RA and demonstrated...
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