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To evaluate the safety of drugs used in infertility treatment.Literature search using the keywords birth defect, congenital malformation, clomiphene, aromatase inhibitor, letrozole, gonadotropin, metformin, gonadotropin releasing hormone agonist and antagonist, progesterone, progestin, and estrogen. We conducted the search in Medline, EMBASE, and Cochrane Database of systematic reviews.The available...
To evaluate the incidence of congenital malformations among offspring of mothers who conceived with clomiphene citrate (CC) or with letrozole treatment for infertility. Retrospective study. 5 fertility centers in Canada. 911 newborns from women who conceived following CC or letrozole treatment. Examination of medical files of both mother and newborn, and cross-checked with the parents...
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