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Melatonin exerts a protective effect during hepatic ischemia–reperfusion (I/R) injury through modulation of the apoptotic cell death program. Mitogen-activated protein kinases mediate various intracellular processes such as cell differentiation, survival, and death. This study investigated whether melatonin exerts a protective effect through the activation of Raf-MEK-ERK and its downstream targets,...
Abstract: Melatonin is a potent scavenger of reactive oxygen species and a strong antioxidant. Melatonin exerts protective effects against damage by the enhancing the Akt signal pathway, thus regulating apoptotic cell death. Akt phosphorylates pro‐apoptotic proteins such as Bad and FoxO1 and inhibits the pro‐apoptotic functions of these proteins. This study investigated the protective effects of...
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