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ATP-sensitive potassium channels (K ATP ) are thought to be targets for antihypertensive drugs that are potassium channel openers. In this study, the expression of genes encoding the K ATP subunits, SUR2, Kir6.1 and Kir6.2, was detected in tissues from Wistar–Kyoto rats (WKY), spontaneously hypertensive rats (SHR), and SHR undergoing long-term treatment with iptakalim, a novel antihypertensive...
Parkinson's disease is characterized by an extensive loss of dopaminergic neurons in the substantia nigra pars compacta. The final common pathway in the demise of these cells may involve dopamine-dependent oxidative stress. Previous studies revealed a new neuronal protective role of ATP-sensitive potassium channel openers. But the exact mechanism is still unknown. In the present study, the neuroprotective...
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