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Haloperidol is a potent dopamine receptor antagonist and used to treat psychotic disorders, such as schizophrenia. Recent clinical and preclinical studies demonstrated the overactivity of the nitric oxide (NO) system in schizophrenia. Neonatal ventral hippocampal (nVH) lesions in rats have been widely used as a neurodevelopmental model that mimics schizophrenia‐like behaviors. Here, we investigate...
We inquired into the biophysical basis of the ability of weak electromagnetic fields (EMFs) to trigger onset and offset evoked potentials, and to produce steady‐state changes in the electroencephalogram (EEG). Rats were exposed to a 2.5‐G, 60‐Hz magnetic field and the neuroanatomical region of glucose activation associated with the effect of the field on the EEG was identified by positron emission...
Cerebellar involvement in autism, schizophrenia, and other cognitive disorders is typically associated with prefrontal cortical pathology. However, the underlying neuronal mechanisms are largely unknown. It has previously been shown in mice that stimulation of the dentate nucleus (DN) of the cerebellum evokes dopamine (DA) release in the medial prefrontal cortex (mPFC). Here, we investigated the neuronal...
Using whole‐brain structural measures coupled to analysis of salivary brain‐derived neurotrophic factor (BDNF), we demonstrate sensory motor training‐induced plasticity, including cerebellar gray matter volume increment and increased BDNF level. The increase of cerebellar volume was positively correlated with the increase of BDNF level.
Parallel fiber synapses in the cerebellum express a wide range of presynaptic receptors. However, presynaptic receptor expression at individual parallel fiber synapses is quite heterogeneous, suggesting physiological mechanisms regulate presynaptic receptor expression. We investigated changes in presynaptic GABAB receptors at parallel fiber‐stellate cell synapses in acute cerebellar slices from juvenile...
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