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Amphiphilic triblock copolymers containing FeIII‐catecholate complexes formulated as spherical‐ or cylindrical‐shaped micellar nanoparticles (SMN and CMN, respectively) are described as new T
1‐weighted agents with high relaxivity, low cytotoxicity, and long‐term stability in biological fluids. Relaxivities of both SMN and CMN exceed those of established gadolinium chelates across a wide range of...
Successful gene therapy of neurological disorders is predicated on achieving widespread and uniform transgene expression throughout the affected disease area in the brain. However, conventional gene vectors preferentially travel through low‐resistance perivascular spaces and/or are confined to the administration site even with the aid of a pressure‐driven flow provided by convection‐enhanced delivery...
Understanding the growth of graphene over Si species is becoming ever more important as the huge potential for the combination of these two materials becomes more apparent, not only for device fabrication but also in energy applications, particularly in Li‐ion batteries. Thus, the drive for the direct fabrication of graphene over Si is crucial because indirect approaches, by their very nature, require...
This study explores the use of human embryonic stem cells (hESCs) for assessing nanotoxicology, specifically, the effect of gold nanoparticles (AuNPs) of different core sizes (1.5, 4, and 14 nm) on the viability, pluripotency, neuronal differentiation, and DNA methylation of hESCs. The hESCs exposed to 1.5 nm thiolate‐capped AuNPs exhibit loss of cohesiveness and detachment suggesting ongoing cell...
A gold nanoshell‐functionalized polymer multilayer nanorocket performs self‐propulsion upon the irradiation with NIR light in the absence of chemical fuel. Theoretical simulations reveal that the NIR light‐triggered self‐thermophoresis drives the propulsion of the nanorocket. The nanorocket also displays efficient NIR light‐triggered propulsion in biofluids and thus holds considerable promise for...
Biological responses to photothermal effects of gold nanoparticles (GNPs) have been demonstrated and employed for various applications in diverse systems except for one important class – plants. Here, the uptake of GNPs through Arabidopsis thaliana roots and translocation to leaves are reported. Successful plasmonic nanobubble generation and acoustic signal detection in planta is demonstrated. Furthermore,...
Irradiation‐induced vacancy defects in multiwalled (MW) boron nitride nanotubes (BNNTs) are investigated via in situ high‐resolution transmission electron microscope operated at 80 kV, with a homogeneous distribution of electron beam intensity. During the irradiation triangle‐shaped vacancy defects are gradually generated in MW BNNTs under a mediate electron current density (30 A cm−2), by knocking...
A chip‐based approach for electrochemical characterization and detection of microsomes and exosomes based on direct electro‐oxidation of metal nanoparticles (MNPs) that specifically recognize surface markers of these vesicles is reported. It is found that exosomes and microsomes derived from prostate cancer cells can be identified by their surface proteins EpCAM and PSMA, suggesting the potential...
Multiscale fluidic reactors with integrated nanoporous membranes enable prolonged cell‐free reactions for efficient therapeutic protein production as required for point‐of‐care needs. S. T. Retterer and co‐workers show on page 810 how the membrane permeability can be tuned to optimize exchange between a primary reaction channel, containing protein production machinery, and a ‘feeder’ channel that...
In order to investigate the defect effect on photocatalytic performance of the visible light photocatalyst, Zn‐Cd‐S solid solution with surface defects is prepared in the hydrazine hydrate. X‐ray photoelectron spectra and photoluminescence results confirm the existence of defects, such as sulfur vacancies, interstitial metal, and Zn and Cd in the low valence state on the top surface of solid solutions...
One‐pot creation of unique concave Pd‐Pt core–shell polyhedra has been developed for the first time using an efficient approach. Due to the concave feature and ultrathin Pt shell, the created Pd‐Pt core–shell polyhedra exhibit enhanced catalytic performance in both the electrooxidation of methanol and hydrogenation of nitrobenzene, as compared with commercial Pt black and Pd black catalysts.
A high‐transmission, multiple antireflective surface inspired by bilayer 3D ultrafine hierarchical structures in butterfly wing scales is fabricated on a glass substrate using wet chemical biomimetic fabrication. Interestingly, the biomimetic antireflective surface exhibits excellent antireflective properties and high transmission, which provides better characteristics than the butterfly wings and...
An improved antitumor therapy can be achieved by rationally designing an intelligent nanomedicine with programmed functions to specifically eliminate tumors while leaving healthy tissues untouched. On page 733, X.‐Z. Zhang and co‐workers demonstrate a tailor‐made ZnO‐based nanococktail with a stealth capacity to trigger an intracellular cascade reaction, releasing drugs on‐demand for tumor‐specific...
A multifunctional nanoparticle based on gold nanorod (GNR), utilizing mRNA triggered chemo‐drug release and near‐infrared photoacoustic effect, is developed for a combined chemo‐photoacoustic therapy. The constructed nanoparticle (GNR‐DNA/FA:DOX) comprises three functional components: (i) GNR as the drug delivery platform and photoacoustic effect enhancer; (ii) toehold‐possessed DNA dressed on the...
Cell‐free protein synthesis (CFPS) is a powerful technology that allows for optimization of protein production without maintenance of a living system. Integrated within micro and nanofluidic architectures, CFPS can be optimized for point‐of‐care use. Here, the development of a microfluidic bioreactor designed to facilitate the production of a single‐dose of a therapeutic protein, in a small footprint...
The first example of mitochondrial delivery of the anticancer drug doxorubicin (Dox) is presented by lipid‐functionalized DNA nanocages (LNCs). Dox localized in mitochondria induces significant cytotoxicity and cellular apoptosis in MCF‐7 compared with Dox localized in lysosomes. These results suggest that LNC has the potential to be an outstanding tool in the treatment of specific organelle‐related...
A highly transmissive, multiple antireflective surface inspired by bilayer 3D ultrafine hierarchical structures in butterfly wing scales is fabricated on a glass substrate using a facile wet‐chemical biomimetic fabrication method. On page 713, S. Niu and co‐workers describe how the biomimetic antireflective surface exhibits not only excellent antireflective properties but also high transmission, which...