The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser.
Robust luminescent dyes with efficient two‐photon fluorescence are highly desirable for biological imaging applications, but those suitable for organic dots fabrication are still rare because of aggregation‐caused quenching. In this work, a red fluorescent silole, 2,5‐bis[5‐(dimesitylboranyl)thiophen‐2‐yl]‐1‐methyl‐1,3,4‐triphenylsilole ((MesB)2DTTPS), is synthesized and characterized. (MesB)2DTTPS...
Cellular uptake of nanomaterials from the bloodstream and their subsequent distribution in tissue is a crucial step for diverse drug delivery approaches. On page 1882, M. Rehberg and co‐workers describe the presence of microtubule‐containing membrane nanotubes connecting perivascular and tissue‐resident macrophages in skeletal muscle tissue. Perivascular macrophages are able to sample nanoparticles...
So‐called membrane nanotubes are cellular protrusions between cells whose functions include cell communication, environmental sampling, and protein transfer. It has been previously reported that systemically administered carboxyl‐modified quantum dots (cQDs) are rapidly taken up by perivascular macrophages in skeletal muscle of healthy mice. Expanding these studies, it is found, by means of in vivo...
Two near‐infrared dyes featuring good dispersion and light‐harvesting property present a remarkable nonlinear photoacoustic response in vitro and in vivo comparing with conventional gold nanorods. This study benefits the fabrication of drug delivery platforms with accurate targeting and control effect under photoacoustic image guidance.
Encapsulation of gold nanorods together with Nd‐doped fluorescent nanoparticles in a biocompatible polymer creates multifunctional nanostructures, whose infrared fluorescence allows their subcutaneous localization in biological tissues while also adding the ability to measure the temperature from the emitted light in order to better monitor the light‐to‐heat conversion of the gold nanorods during...
Light upconversion is a very powerful tool in bioimaging as it can eliminate autofluorescence, increase imaging contrast, reduce irradiation damage, and increase excitation penetration depth in vivo. In particular, triplet–triplet annihilation upconverting (TTA‐UC) nanoparticles and liposomes offer high upconversion efficiency at low excitation power. However, TTA‐UC is quenched in air by oxygen,...
Organic dots composed of emissive aggregates of aggregation‐induced emission (AIE) luminogens and biocompatible polymeric matrices are emerging as promising reagents for bioimaging, owing to various merits including strong photoluminescence, high photostability, low toxicity and facile functionalization. On page 6430, X. Lou, Z. Zhao, and B. Z. Tang present the excellent performances of AIE dots in...
The combination of diagnosis and therapeutics into one theranostics system has attracted great interest in life science and biomedical fields. The current theranostic platform largely relies on the integration of multiple materials with different functionalities. The all‐in‐one approach has the risk of high complicity with reduced reproducibility. Smart design of simple molecules born with multifunctions...
Two‐photon fluorescence imaging technique is a powerful bioanalytical approach in terms of high photostability, low photodamage, high spatiotemporal resolution. Recently, fluorescent organic dots comprised of organic emissive cores and a polymeric matrix are emerging as promising contrast reagents for two‐photon fluorescence imaging, owing to their numerous merits of high and tunable fluorescence,...
A multifunctional theranostic platform based on conjugated polymer nanoparticles (CPNs) with tumor targeting, fluorescence detection, photodynamic therapy (PDT), and photothermal therapy (PTT) is developed for effective cancer imaging and therapy. Two conjugated polymers, poly[9,9‐bis(2‐(2‐(2‐methoxyethoxy)ethoxy)‐ethyl)fluorenyldivinylene]‐alt‐4,7‐(2,1,3‐benzothiadiazole) with bright red emission...
Multifunctional conjugated polymer nanoparticles (CPNs) are developed for image‐guided phototherapy by D. Ding, B. Liu, and co‐workers in article number 1602807. Under proper light irradiation, these CPNs display bright red fluorescence, efficient singlet oxygen generation and excellent photothermal conversion abilities. With affibody decoration, these CPNs show excellent tumor targeting and synergistic...
Emerging nanotechnologies show unprecedented advantages in accelerating cancer theranostics. Among them, two‐dimensional nanomaterials (2DNMs) represent a novel type of material with versatile physicochemical properties that have enabled a new horizon for applications in both cancer diagnosis and therapy. Studies have demonstrated that 2DNMs may be used in diverse aspects, including i) cancer detection...
In article number 1603340, by Dingbin Liu and co‐workers, an interference‐free surface‐enhanced Raman scattering tag is constructed to profile the expression of cancer biomarkers at the single‐cell level. The Raman tags present a strong and sharp peak in the cellular Raman‐silent region, significantly diminishing the background interference. Moreover, the reporters are embedded in layered gold nanoparticles,...
An interference‐free surface‐enhanced Raman scattering tag is constructed to profile the expression of cancer biomarkers at the single‐cell level. The Raman tags present a strong and sharp peak in the cellular Raman‐silent region, significantly diminishing the background interference. Moreover, the reporters are embedded in the layered gold nanoparticles, avoiding desorption and enzymatic degradation...
Photodynamic therapy (PDT) based on photosensitizers (PSs) constructed with nanomaterials has become popular in cancer treatment, especially oral carcinoma cell. This therapy is characterized by improved PS accumulation in tumor regions and generation of reactive oxygen species (ROS) for PDT under specific excitation. In the selection of near‐infrared (NIR) window, 808 nm NIR light because it can...
In article number 1700038, Michael Hsiao, Ru‐Shi Liu, and co‐workers, report an 808 nm near‐infrared‐triggered photodynamic therapy (PDT) strategy using upconversion nanoparticle‐poly‐l‐lysine@graphitic carbon nitride quantum dots (UCNP‐PLL@CNs) nanocomposites. The 808 nm UCNP‐PLL@CNs are expected to make PDT more humane, controllable, and low‐cost, which will inevitably lead to considerable improvements...
Near infrared (NIR) light triggered phototherapy including photothermal therapy (PTT) and photodynamic therapy (PDT) affords superior outcome in cancer treatment. However, the reactive oxygen species (ROS) generated by NIR‐excited upconversion nanostructure is limited by the feeble upconverted light which cannot activate PDT agents efficiently. Here, an IR‐808 dye sensitized upconversion nanoparticle...
Highly reliable detection, imaging, and monitoring of reactive oxygen species (ROS) are critical for understanding and studying the biological roles and pathogenesis of ROS. This study describes the design and synthesis of myoglobin and polydopamine‐engineered surface‐enhanced Raman scattering (MP‐SERS) nanoprobes with strong, tunable SERS signals that allow for specifically detecting and imaging...
Here a multifunctional nanoplatform (upconversion nanoparticles (UCNPs)‐platinum(IV) (Pt(IV))‒ZnFe2O4, denoted as UCPZ) is designed for collaborative cancer treatment, including photodynamic therapy (PDT), chemotherapy, and Fenton reaction. In the system, the UCNPs triggered by near‐infrared light can convert low energy photons to high energy ones, which act as the UV–vis source to simultaneously...
2D carbon and nitrogen based semiconductors (CN) have attracted widespread attention for their possible use as low‐cost and environmentally friendly materials for various applications. However, their limited solution‐dispersibility and the difficulty in preparing exfoliated sheets with tunable photophysical properties restrain their exploitation in imaging‐related applications. Here, the synthesis...
Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.