The seizures that persist beyond the neonatal period often result from cerebral pathology such as developmental brain anomalies or are part of an epilepsy syndrome. Neonatal and infantile seizures may reflect heightened propensity for the immature brain to manifest ictal events under conditions that may not trigger the same responses in other age groups. This chapter presents a list of the approved and non‘approved drugs for treatment of seizures in the neonatal period and infants. Some of the drugs include benzodiazepines, levetiracetam, phenobarbital, phenytoin and topiramate. Approximately one‘third of patients with epilepsy present with seizures that are refractory to treatment with two or more antiepileptic drugs (AEDs). A ketogenic diet, surgery, and neurostimulation offer alternative treatment options for these individuals. Rapid diagnosis, correct identification of aetiology, and successful AED treatment of neonatal and infantile seizures are important to prevent adverse sequelae and improve long‐term outcomes.