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Background
Invasive mucormycosis is a rare but frequently fatal fungal disease. The acute and rapidly progressive evolution causes unfavourable outcome in 22%‐59% of patients and its treatment represents a clinical challenge, especially in immunocompromised patients. Current data in paediatric oncological patients are limited.
Objectives
The infection Working Group of the Italian Association of...
Background
The wide pharmacokinetic variability of voriconazole leads to uncertainty regarding adequate exposure.
Objectives
To create a pharmacokinetic model that could help to explain the variability.
Methods
Retrospective review of paediatric patients with cancer. Models were built using Pmetrics.
Results
We analysed 158 trough measurements in 55 patients; in 41.8%, the serum levels were...
The cut‐offs for total and specific IgE used for diagnosing ABPA in children have been adopted from adult literature and have not been validated in the paediatric population. To establish the ideal cut‐offs of total IgE and Aspergillus‐specific IgE for the diagnosis of ABPA in children. This study was a prospective observational case‐control study, conducted in a tertiary care hospital in North India,...
Background
Autologous hematopoietic stem cell transplantation (HSCT) carries risks of infectious morbidity. We analysed epidemiology and management burden associated with invasive fungal diseases (IFDs) in children and adolescents undergoing autologous HSCT.
Methods
In a retrospective, single‐centre observational study, epidemiology and management burden associated with IFDs were analysed in all...
Mucormycosis represents a real challenge in immunocompromised patients. This study aimed to describe the clinical characteristics, treatment outcome and infection‐related mortality in our patients at the Children's Cancer Hospital 57357, Cairo, Egypt. This is a retrospective study during the period 2007‐2017. Data analysis included demographic data, risk factors, diagnostic workup, treatment and outcome...
The objective of the study was the analysis of incidence and outcome of invasive fungal disease (IFD) in children treated for malignancy (PHO, paediatric hematology‐oncology) or undergoing hematopoietic cell transplantation (HCT) over a period of six consecutive years in nationwide study. A total number of 5628 patients with newly diagnosed malignancies and 971 patients after HCT (741 allo‐HCT and...
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