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5‐Fluorouracil (5‐FU) is a clinically well‐established anti‐cancer drug effectively applied in chemotherapy, mainly for the treatment of breast and colorectal cancer. Substantial disadvantages are adverse effects, arising from serious damage of healthy tissues, and shortcoming pharmacokinetics due to its low molecular weight. A promising approach for improvement of such drugs is their coupling to...
An optimized condition is identified to prepare linear poly(amido amine)s via Michael Addition polymerization of trifunctional amine, 4‐(aminomethyl)piperidine (AMPD), with an equimolar diacrylamide, N,N‐cystaminebis(acrylamide) (BAC). Poly(ethylene glycol) (PEG) and cholesterol (CE) are conjugated to linear poly(BAC‐AMPD) through the reactions with the secondary amino groups in the backbone, respectively,...
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