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The heterotrimeric G‐protein Go with its splice variants, Go1α and Go2α, seems to be involved in the regulation of motor function but isoform‐specific effects are still unclear. We found that Go1α‐/‐ knockouts performed worse on the rota‐rod than Go2α‐/‐ and wild‐type (WT) mice. In Go1+2α‐/‐ mice motor function was partially recovered. Furthermore, Go1+2α‐/‐ mice showed an increased spontaneous motor...
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