Background
Diffusion‐kurtosis imaging (DKI) has preliminarily shown promise as a relatively new MRI technique to provide useful information regarding breast lesions, but the diagnostic performance of DKI has not been fully evaluated.
Purpose
To compare the diagnostic accuracy of DKI, diffusion‐weighted imaging (DWI), dynamic contrast‐enhanced (DCE)‐MRI) and proton MR spectroscopy (1H‐MRS) in differentiating malignant from benign breast lesions independently or jointly, and explore the correlation between DKI‐derived parameters and prognostic factors.
Study Type
Prospective.
Subjects
Seventy‐one patients with breast lesions (50 malignant, 26 benign).
Sequence
DKI, DWI, DCE‐MRI, and 1H‐MRS were performed at 3.0T.
Assessment
Mean kurtosis (MK), mean diffusivity (MD), apparent diffusion coefficient (ADC), BI‐RADS category, and choline peaks were analyzed by two experienced radiologists.
Statistical Tests
Student's t‐test was used for continuous variables; receiver operating characteristic (ROC) analysis for assessing the diagnostic accuracy of imaging parameters; Spearman or Pearson correlations for assessing the associations between imaging parameters and prognostic factors.
Results
MK exhibited higher area under the curves (AUCs) for differentiating malignant from benign lesions than did MD, ADC, DCE, and tCho (0.979 vs. 0.928, 0.911, 0.777, and 0.833, respectively, P < 0.05). MK showed a positive association with Ki‐67 expression (r = 0.508) and histologic grades (r = 0.551), whereas MD and ADC were negatively correlated with Ki‐67 expression (r = –0.416 and r = –0.458) and histologic grades (r = –0.411 and r = –0.319). Moreover, MK showed relatively higher AUCs compared with MD and ADC in detecting breast cancers with lymph nodal involvement, histologic grades, and Ki‐67 expression.
Data Conclusion
MK has higher diagnostic accuracy compared with ADC, DCE, and tCho regarding detection of breast cancer. Moreover, DKI shows promise as a quantitative imaging technique for characterizing breast lesions, highlighting the potential utility of MK as a promising imaging marker for predicting tumor aggressiveness.
Level of Evidence: 2
Technical Efficacy: Stage 2
J. Magn. Reson. Imaging 2019;49:845–856.