Background
Coronary artery disease (CAD) was the second leading cause of death for the past 3 years in Taiwan. The insulin‐like growth factor (IGF) system is considered a new risk factor of CAD because investigations show that the levels and bioactivity of IGF‐I and IGFBP‐3 (where IGFBP is insulin‐like growth factor‐binding protein) may be involved in elevating the risk of CAD. This study investigated the relationships among IGF‐I +1770, IGF‐I +6093, and IGFBP‐3 ‐202 genetic polymorphisms and CAD in the Taiwanese population.
Methods
A total of 581 subjects, including 390 non‐CAD controls and 191 patients with CAD, were recruited and the isolated DNA was subjected to real‐time polymerase chain to evaluate the effects of these three polymorphic variants on CAD.
Results
Our results showed a significant association between the IGF‐I +1770 gene polymorphism and increased risk of CAD. Furthermore, CAD patients with a minimum of one mutant C allele, T/C or C/C, in IGF‐I +1770 gene polymorphism had significantly high blood pressure including systolic blood pressure (SBP; P = 0.025) and diastolic blood pressure (DBP; P = 0.004), compared to CAD patients with T/T homozygotes. Moreover, CAD patients with a minimum of one mutant A allele, G/A or A/A, in the IGF‐I +6093 gene polymorphism had a 1.695‐fold elevated risk of congestive heart failure (CHF), compared to CAD patients with the G/G homozygote.
Conclusions
Polymorphism of IGF‐I +1770 was associated with increased CAD risk. In CAD patients, the contributions of IGF‐I +1770 and +6093 could be through the effect on blood pressure in CAD patients. J. Clin. Lab. Anal. 27:162–169, 2013. © 2013 Wiley Periodicals, Inc.