Journal of Biomedical Materials Research Part B: Applied Biomaterials
The aim of this study was to investigate the osteogenic effect of three different cell‐seeded 3D‐bioplotted scaffolds in a ovine calvarial critical‐size defect model. The choice of scaffold‐materials was based on their applicability for 3D‐bioplotting and respective possibility to produce tailor‐made scaffolds for the use in cranio‐facial surgery for the replacement of complex shaped boneparts. Scaffold...
Wound dressings aim to restore the milieu required for skin regeneration and protect the wound from environmental threats, including penetration of bacteria. The dressings should be easy to apply and remove and maintain a moist healing environment. In this study, novel biodegradable composite wound dressings based on a polyglyconate mesh and a porous PDLGA binding matrix were developed and studied...
Tissue‐engineering scaffold‐based strategies have suffered from limited cell depth viability when cultured in vitro, with viable cells existing within the outer periphery of the fluid–scaffold interface. This is primarily believed to be due to the lack of nutrient delivery into and waste removal from the inner regions of the scaffold construct. This work develops a hydroxyapatite trimodal porous scaffold...
The objectives of this study were three‐fold: (1) to determine the applicability of the small punch test to characterize Bionate® 80A polycarbonate urethane (PCU) acetabular implants; (2) to evaluate the susceptibility of PCU acetabular implants to exhibit degradation of mechanical behavior following gamma irradiation in air and accelerated aging; and (3) to compare the oxidation of gamma‐air sterilized...
The classical wear mechanisms abrasion, fatigue, and adhesion are the most frequent causes of surface changes of ultra high molecular weight polyethylene (UHMWPE) in artificial joints. The counterpart material has a strong influence on the wear and friction behavior of artificial joints due to its abrasive properties and adhesive interaction with UHMWPE. The formation of a transfer layer on the counterpart...
Poly(vinyl alcohol) (PVA) is a biocompatible polymer already used in several pharmaceutical products. The purpose of this work was to investigate the influence of freezing–thawing cycles (F/T) on the in vitro diffusion and skin vasodilator properties of S‐nitrosoglutathione (GSNO)‐releasing PVA films. Films subjected to 1‐, 3‐, and 5‐F/T showed an increase in crystallinity, which is associated with...
Silver nanoparticle containing silica coatings on soda‐lime glass were prepared by the sol–gel process. The effect of thermal densification treatment at different temperatures in the range of 100–700°C on microstructure and antibacterial properties of the coatings were examined. The structural characterization of the coatings was performed by using scanning electron microscope, X‐ray diffraction,...
This study sought to evaluate the microhardness of root dentine adjacent to glass‐ionomer and composite resin restorations after erosive challenge. A crossover study was performed in two phases of 4 consecutive days each. One hundred twelve bovine root dentine slabs were obtained, and standardized box‐shaped cavities were prepared at center of each specimen. The prepared cavities were randomly restored...
Bioadhesive polymers are natural or synthetic materials that can be used for soft tissue repair. The aim of this investigation was to develop an injectable, bioadhesive hydrogel with the potential to serve as a synthetic replacement for the nucleus pulposus of the intervertebral disc or as an annulus closure material. Branched copolymers of poly(N‐isopropylacrylamide) (PNIPAAm) and poly(ethylene glycol)...
By using a premixed calcium phosphate cement (CPC), the handling properties of the cement are drastically improved, which is a challenge for traditional injectable CPCs. Previously premixed cements have been based on apatitic cements. In this article, acidic cement has been developed and evaluated. Monocalcium phosphate monohydrate and β‐tricalcium phosphate were mixed with glycerol to form a paste...
Titanium and titanium alloys are widely used in biomedical devices and components, especially as hard tissue replacements as well as in cardiac and cardiovascular applications, because of their desirable properties, such as relatively low modulus, good fatigue strength, formability, machinability, corrosion resistance, and biocompatibility. However, titanium and its alloys cannot meet all of the clinical...
This study presents experiments designed to study the stability of the conducting polymer poly(3,4‐ethylene dioxythiophene) (PEDOT), under simulated physiological conditions using phosphate‐buffered saline (PBS) and hydrogen peroxide (H2O2) (0.01M) at 37°C over a 5‐ to 6‐week period. Voltage pulsing in PBS was used as an additional test environment. The influence of switching the counter ion used...
The present study was designed to investigate whether the formation of octacalcium phosphate (OCP) is accelerated on titanium (Ti) surface by an electron cyclotron resonance (ECR) plasma oxidation at various pressures and temperatures. X‐ray diffraction (XRD) of Ti‐oxidized substrates showed that the rutile TiO2 phase on its surfaces appeared at 300°C and was crystallized when the oxidation temperature...
The purpose of this study was to perform an intra‐animal comparison of biodegradable woven fabrics made of bioactive glass (BG) fibers and poly(L‐lactide‐co‐glycolide) 80/20 copolymer (PLGA80) fibers or PLGA80 fibers alone, in surgical stabilization of bone graft. The BG fibers (BG 1‐98) were aimed to enhance bone growth at site of bone grafting, whereas the PLGA component was intended to provide...
Injectable hydrogels may potentially be used for augmentation/regeneration of the lamina propria of vocal fold tissue. In this study, hyaluronic acid (HA) and dextran were chemically modified and subsequently crosslinked via formation of hydrazone bonds in phosphate buffer. Swelling ratios, degradation, and compressive moduli of the resulting hydrogels were investigated. It was found that the properties...
Dental curing lights deliver energy in the 380–520 nm wavelength range. It has been reported that irradiation in these wavelengths may have a negative effect on cell function. We examined the effect of three dental curing lights on the viability of mouse (NIH3T3, Balb/c3T3) and human (HGF‐1) fibroblastic cells, and epithelial (HT‐29) cells grown in culture. Cell inhibition was observed using the MTT...
Alginate is widely used for cell microencapsulation and transplantation. There is a lack of standardization of alginate purity and composition. In a previous study, we compared different alginate purification methods and concluded that polyphenol and endotoxin contaminants were eliminated efficiently but residual protein contaminants persisted with all of the methods under evaluation. The objective...
In this study, the friction and wear behavior of ultrahigh molecular weight polyethylene (UHMWPE) were evaluated as a function of polymer crystallinity in the presence of the phospholipid dipalmitoyl phosphatidylcholine (DPPC) dissolved in ethanol. Samples of UHMWPE were separately heat treated to get high and low crystallinity samples. Degree of crystallinity was evaluated using differential scanning...
Few published studies describe the biological properties of calcium phosphate cements (CPCs) for dental applications. We measured several biologically relevant properties of 3 CPCs over an extended (8 wk) interval. Monocalcium phosphate, calcium oxide, and synthetic hydroxyapatite were combined with either modified polyacrylic acid, light‐activated modified polyalkenoic acid, or 35% w/w polymethyl...
Objective: To prepare the Gd‐DTPA‐loaded poly (lactic‐co‐glycolic acid) (PLGA) microbubbles for both ultrasound imaging and MRI imaging. Methods: Biodegradable high‐molecular‐weight poly (lactic‐co‐glycolic acid) (PLGA) was used as an encapsulating vehicle to fabricate a contrast agent composed of gadolinium diethylenetriamine pentaacetic acid (Gd‐DTPA) and fluorocarbon‐filled microbubbles by using...