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Ti‐24Nb‐4Zr‐7.9Sn (TNZS) is a newly developed β‐titanium alloy with low modulus and it has been considered as good material for dental or orthopedic implant. The purpose of the current study is to evaluate the effect of micro‐arc oxidation (MAO) treatment on the biological performance of TNZS surface. The phases, morphology and chemical composition of the MAO‐treated surface were characterized by...
A peptide containing a RGD (arginine‐glycine‐aspartic acid) sequence as well as a hydrophobic N‐fluorenyl‐9‐methoxycarbonyl (FMOC) tail was prepared via a standard FMOC solid‐phase peptide synthesis technique. The supramolecular self‐assembly of such peptide through π–π stacking from FMOC tail can transfer the peptide aqueous solution into a three‐dimensional hydrogel. The biocompatibility of the...
Porous metals (sintered beads and meshes) have been used for many years for different orthopedic applications. Metal foams have been recently developed. These foams have the advantage of being more porous than the traditional coatings. Their high porosity provides more space for bone ingrowth and mechanical interlocking and presents more surface for implant‐bone contact. The objective of this study...
A novel injectable bone cement based on mineralized collagen was reported in this paper. The cement was fabricated by introducing calcium sulfate hemihydrate (CaSO4·1/2H2O, CSH) into nano‐hydroxyapatite/collagen (nHAC). The workability, in vitro degradation, in vitro and in vivo biocompatibility of the cement (nHAC/CSH) were studied. The comparative tests via in vitro and in vivo showed that the nHAC/CSH...
In this study, we investigated cellular biocompatibility in vitro and segmental bone defect repairing efficacy in vivo of a previously reported fibre‐reinforced scaffold, nano‐hydroxyapatite/collagen/poly (L‐lactic acid) (PLLA)/chitin fibres (nHACP/CF). First, attachment, proliferation, and differentiation of the goat bone mesenchymal stem cells (GBMSCs) cultured on the nHACP/CF scaffolds were evaluated...
Technical development for an efficient coating of bioactive materials improves the characteristics of a fully functional implant. The aim of this study was to investigate the osteoinductive effect of a newly developed hydroxyapatite (HA)‐coating technique using aerosol deposition without post‐heat treatment [room temperature (RT) group] on the titanium (Ti) dental implant in vitro and in vivo, compared...
One of the main problems in healthcare is the loss of tissues resulting from diseases, post‐surgery complications or trauma. As a result there is a need for biomaterials designed to promote tissue regeneration and improve wound healing. This study assessed the effect of crosslinking of a porcine dermal collagen matrix with regard to strength of implant/host tissue integration, implant biocompatibility...
Human acellular nerve grafts (ANGs) have been rarely used to construct tissue‐engineered nerves compared to the animal‐derived ANGs, and their potential clinical applications were relatively unknown. In this study, it was aimed to investigate the structure and components of a scaffold derived from human peripheral nerve and evaluate its biocompatibility. The human peripheral nerves were processed...
Di (2‐ethyl hexyl) phthalate (DEHP) is one of the main plasticizers used in poly(vinyl chloride) (PVC) medical devices and is currently the only one listed for use in the European Pharmacopoeia Monograph. It leaches out of PVC when the material is in contact with lipophilic media, for example, blood and certain nutritional feeds. Consequently, concerns have been expressed since in certain animal species,...
The current study focused on doping of hydroxyapatite (HA) with constant yttrium (Y3+) and varying fluoride (F−) compositions to investigate its microstructure, microhardness, and biocompatibility. HA was synthesized by precipitation method and sintered at 1100°C for 1 h. Y3+ and F− ion dopings resulted in changes in densities. In x‐ray diffraction analysis, no secondary phase formation was observed...
Hydroxyapatite (HA) coatings loaded with nanosilver particles is an attractive method to impart the HA coating with antibacterial properties. Producing Ag/HA coatings on porous Ti substrates have been an arduous job since commonly used line‐of‐sight techniques are not able to deposit uniform coatings on the inner pore surfaces of the porous Ti. In this study, porous Ti scaffolds with high porosity...
Implantable devices realized by microfabrication have introduced a new class of potential biomaterials whose properties would need to be assessed. Such devices include sensors for measuring biological substances like glucose. Thus, 14 different candidate materials intended for design of such a device were investigated with respect to their complement activation potential in human serum. The fluid‐phase...
Silk fibroin has been successfully used as a biomaterial for tissue regeneration. To prepare silk fibroin biomaterials for human implantation a series of processing steps are required to purify the protein. Degumming to remove inflammatory sericin is a crucial step related to biocompatibility and variability in the material. Detailed characterization of silk fibroin degumming is reported. The degumming...
Biodegradable isocyanate‐functional adhesives based on poly(ethylene glycol)–adipic acid esters were synthesized, characterized, and evaluated in vitro and in vivo. Two types of formulations, P2TT and P2MT, were developed by functionalization with 2,4‐tolylene diisocyanate (TDI) or 4,4′‐methylene‐bis(phenyl isocyanate) (MDI), respectively, and branching with 1,1,1‐trimethylolpropane (TMP). The biocompatibility...
We investigated the effect of sustained release of bone morphogenetic protein‐2 (BMP‐2) from an injectable chitosan gel on osteoblastic differentiation in vitro. We first characterized the release profile of BMP‐2 from the gels, and then examined the cellular responses of preosteoblast mouse stromal cells (W‐20‐17) and human embryonic palatal mesenchymal (HEPM) cells to BMP‐2. The release profiles...
Implantation of synthetic materials into body elicits inflammatory host responses that limit medical device integration and biological performance. Since the effective use of biomaterials in vivo requires good biocompatibility and bio‐functionality, it is vital that we assess the inflammatory reactions provoked by various implanted biomaterials. In chemical precipitation of β‐tricalcium phosphate...
Pectins, complex plant‐derived polysaccharides, are novel candidates for biomaterial nanocoatings. Pectic rhamnogalacturonan‐I regions (RG‐I) can be enzymatically treated to so‐called modified hairy regions (MHR). We surveyed the growth and differentiation of murine preosteoblastic MC3T3‐E1 cells on Petri dishes coated with RG‐Is from native or genetically engineered potato tubers. Uncoated tissue...
The biodegradable polylactide/poly(ethylene glycol) (PLA/PEG) hybrid membranes were fabricated via electrospinning of PLA/PEG solution. Their structures and properties were investigated by scanning electron microscopy, differential scanning calorimetry, and water contact angle. In vitro hydrolytic degradation showed that PEG content influenced the degradation rate of the PLA/PEG hybrid mats. The mechanical...
Naturally occurring biomaterial scaffolds derived from extracellular matrix (ECM) have been the topic of recent investigation in the context of rotator cuff tendon repair. We previously reported a method to treat fascia ECM with high molecular weight tyramine substituted‐hyaluronan (TS‐HA) for use as a tendon augmentation scaffold. The presence of crosslinked TS‐HA in fascia was associated with an...
Titanium alloys are still on the top list of fundamental materials intended for dental, orthopedics, neurological, and cardiovascular implantations. Recently, a special attention has been paid to vanadium‐free titanium alloy, Ti6Al7Nb, that seems to represent higher biocompatibility than traditional Ti6Al4V alloy. Surprisingly, these data are not thoroughly elaborated in the literature; particularly...
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