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Seventy percent of all cervical cancers are caused by human papillomavirus (HPV) infections. Natural products are being extensively explored for their potential ability to prevent and treat cervical cancers. N‐benzylcinnamide (PT‐3) is a natural product purified from Piper submultinerve. Whether or not PT‐3 has an effect on cervical cancer cells is as yet unknown. Therefore, we set out to explore...
Two human papillomavirus (HPV) viral oncoproteins, E6 and E7 represent ideal targets for development of a therapeutic HPV vaccine. It is important to reduce the rate of HPV‐associated malignancies through improvement of vaccine modalities. In this study, we used a short amphipathic peptide carrier, Pep‐1, for delivery of the full‐length HPV16 E7 protein into mammalian cells and evaluated immune responses...
Therapeutic human papillomaviruse (HPV) vaccines have the potential to inhibit the tumor growth by targeting HPV E6 and E7 oncoproteins. Among different vaccine strategies, DNA and protein‐based approaches are the most effective candidates for stimulation of the immune responses against HPV infections. Our study was designed to assess the efficacy of small heat shock proteins B1 (Hsp27) and B6 (Hsp20)...
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