The veterinary cancer patient's daily comfort level is of utmost importance to all involved in their treatment and is a key indicator of perceived quality of life for pet owners. When the cancer team communicates with owners, it is important that realistic expectations and parameters are established so that as the veterinary cancer patient enters the final stages of disease and the team can provide the best possible care. This should include a multimodal approach that includes pain relief, physical rehabilitation/therapy, environmental adaptive care, nutritional support, quantifying quality of life, hospice care, and bereavement support. Nonsteroidal anti‐inflammatory drugs (NSAIDs) are used in cats for pain management, because cats metabolize these differently than dogs, care must be taken with dosing intervals. Rehabilitation modalities can include therapeutic exercises and stretching, aquatic therapy, therapeutic massage and joint manipulation, the application of heat and cold, therapeutic ultrasound, electrical stimulation, magnetic fields, and extracorporeal shockwaves.