CeCl3 «71120 and GdCl3‐6H20 that were dissolved in water were precipitated with urea to produce matrix agglomerates for three‐component nano‐reactors. Nano‐reactors were produced by impregnating the nano‐C3H6N606 into the matrix agglomerates of an intermediate complex of cerium and gadolinium compounds. Blast initiation of the CˆsˆOs resulted in extremely rapid detonation and gaseous products formation at temperatures of 2000°‐5000°C, which were compressed into a volume nearly equal to the initial volume of each RDX nano‐particle. Multiple “nano‐blasts” occurred in the volume of each nano‐reactor. This chapter focuses on establishing a new method of preparing nano‐size, agglomerate‐free, cerium‐gadolinium oxide (CGO) ceramic powders with precise morphology and chemical composition. During the past decade, Ce02‐based materials have been intensively investigated as catalysts, structural and electronic promoters of heterogeneous catalytic reactions, and oxygen‐ion conducting solid electrolytes in electrochemical solid oxide fuel cells4'23'24.