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Genome‐wide association studies (GWAS) have been successful in their search for common genetic variants associated with complex traits and diseases. With new advances in array technologies together with available genetic reference sets, the next generation of GWAS will extend the search for associations with uncommon SNPs (1% ⩽ MAF ⩽ 10%). Two possible approaches are genotyping all participants, a...
Not accounting for interaction in association analyses may reduce the power to detect the variants involved. We investigate the powers of different designs to detect under two‐locus models the effect of disease‐causing variants among several hundreds of markers using family‐based association tests by simulation. This setting reflects realistic situations of exploration of linkage regions or of biological...
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