Background and purpose
The aim of this study was to discover the associations between HMOX‐1 and Alzheimer's disease (AD).
Methods
A total of 500 AD patients and 500 healthy controls were recruited in this study. Polymer chain reaction was used.
Results
There was a statistically significant difference between AD patients and controls in both the dominant and recessive models of HMOX‐1 rs2071746 after adjustment for age, gender and education (dominant model: p = 0.047, odds ratio [OR] 1.34, 95% confidence interval [CI] 1.00–1.78, adjusted; recessive model: p = 0.049, OR 1.34, 95% CI 1.00–1.80, adjusted). There was also a trend for an association between the dominant model and late‐onset AD after adjustment for age, gender and education (dominant model: p = 0.084, OR 1.37, 95% CI 0.96–1.95, adjusted).
Conclusions
We found an association between the dominant and recessive models of HMOX1 rs2071746 and AD.