Objective
Autologous stem cell transplantation (ASCT) has improved progression‐free survival (PFS) and overall survival in eligible patients with newly diagnosed multiple myeloma (NDMM); however, relapse occurs. Maintenance therapy with lenalidomide (Len‐Mt) extends survival and delays relapse and the subsequent initiation of costly second‐line regimens. Here, we report the cost‐effectiveness of Len‐Mt following ASCT from a Dutch healthcare service perspective.
Methods
A partitioned survival model was developed to assess the lifetime costs and benefits for patients with NDMM. Efficacy was taken from a pooled meta‐analysis of clinical trial data. Costs and subsequent therapy data were taken from sources appropriate for the Dutch market.
Results
Lenalidomide produced a quality‐adjusted life year gain of 2.46 and a life year gain of 2.79 vs no maintenance treatment. The cost of lenalidomide was partially offset by savings of EUR 77 462 in subsequent treatment costs. The incremental cost‐effectiveness ratio of Len‐Mt vs no maintenance treatment was EUR 30 143. Key model drivers included subsequent therapies, dosing schedule, and time horizon.
Conclusion
Lenalidomide is cost‐effective after ASCT vs no maintenance therapy in the Netherlands. By extending PFS, lenalidomide delays the cost burdens associated with relapse and subsequent treatment lines.