Aim
The aim of the present study was to assess the safety and efficacy of CO2 during double‐balloon enteroscopy (DBE) in an experimental animal model study. In this study, insufflation with room air and with CO2 was compared.
Methods
Twenty healthy swines were used. The animals were randomly allocated to two groups. The room air‐DBE group was insufflated with room air, whereas the CO2‐DBE group was insufflated with CO2. Endoscopy duration was 90 min. The following parameters were measured during the study (basal, 30 min, 60 min, 90 min): invasive hemodynamic parameters, ventilatory parameters, arterial blood gases, exploration depth, as well as biochemical tests. Residual gas was evaluated at the end of DBE, at 180 min and 24 h after DBE.
Results
During the endoscopic exploration none of the animals showed hemodynamic, ventilatory or arterial blood gas alterations in the normal reference range for the swine species. The CO2 group showed statistically significant differences over the room air group with lower post‐procedure residual gas and greater depth of the small bowel explored.
Conclusion
The use of CO2 for insufflation during DBE was safe and no complications associated with CO2 were observed. In addition, the use of CO2 offers benefits over the use of room air for insufflation during DBE.