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BACKGROUND
Postoperative management of prostate cancer with lymph node involvement (LNI) is controversial. Retrospective evidence supports the selective use of radiotherapy (RT) after extended pelvic lymph node dissection. It is unclear whether this is generalizable to practice in the United States, where extended dissection is uncommon. The authors identified patients with LNI who potentially could...
BACKGROUND
Cancer and its treatment lead to increased financial distress for patients. To the authors' knowledge, to date, no standardized patient‐reported outcome measure has been validated to assess this distress.
METHODS
Patients with AJCC Stage IV solid tumors receiving chemotherapy for at least 2 months were recruited. Financial toxicity was measured by the COmprehensive Score for financial...
BACKGROUND
The National Pediatric Oncology Unit (UNOP) is the only pediatric hemato‐oncology center in Guatemala.
METHODS
Patients ages 1 to 17 years with acute lymphoblastic leukemia (ALL) were treated according to modified ALL Intercontinental Berlin‐Frankfurt‐Münster (IC‐BFM) 2002 protocol. Risk classification was based on age, white blood cell count, immunophenotype, genetics (when available),...
BACKGROUND
Brief tools are needed to screen oncology outpatients for depressive symptoms.
METHODS
Patients starting radiotherapy for the first diagnosis of any tumor completed distress screening tools, including the 9‐item Patient Health Questionnaire (PHQ‐9), the 2‐item Patient Health Questionnaire (PHQ‐2), the National Comprehensive Cancer Network Distress Thermometer (NCCN‐DT), and the Hopkins...
BACKGROUND
Two large‐scale prostate cancer screening trials using prostate‐specific antigen (PSA) have given conflicting results in terms of the efficacy of such screening. One of those trials, the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, previously reported outcomes with 13 years of follow‐up. This study presents updated findings from the PLCO trial.
METHODS
The PLCO...
BACKGROUND
In previous work, a single administration of anticarcinoembryonic antigen (anti‐CEA) 131I‐labetuzumab radioimmunotherapy (RIT) after complete resection of colorectal liver metastases was well tolerated and significantly improved survival compared with controls. In the current phase 2 trial, the authors studied repeated RIT in the same setting, examining safety, feasibility, and efficacy...
BACKGROUND
In the past 3 decades, a better understanding of gene mutations and their role in carcinogenesis has led to improvement in our ability to treat patients with metastatic disease. The objective of the current study was to determine whether the location of a driver mutation within an affected gene impacts the biology of metastatic colorectal cancer.
METHODS
DNA was collected from 165 randomly...
BACKGROUND
Although laryngectomy is the treatment of choice for patients with T4 larynx cancer, many patients are unable or unwilling to undergo laryngectomy and instead pursue larynx‐preservation strategies combining radiotherapy (RT) and chemotherapy. Herein, the authors analyzed the National Cancer Data Base to evaluate overall survival (OS) between patients treated with surgical and organ‐preserving...
To evaluate histologic subtype and grade, which in turn guide the decision making for multimodality therapy, the workup of suspected sarcoma requires more material than can be obtained from a fine‐needle aspiration. Either open or percutaneous core needle biopsy is indicated before a management decision is made. Percutaneous biopsy of a potentially malignant lesion is controversial, given the perceived...
BACKGROUND
The outcome of patients with higher‐risk myelodysplastic syndromes (MDS) after hypomethylating agent (HMA) failure is poor. This study evaluated the safety and activity of a combination of low‐dose clofarabine and cytarabine for these patients.
METHODS
Seventy patients with higher‐risk MDS who had no response, progressed, or relapsed after at least 4 cycles of HMA therapy were treated...
BACKGROUND
Individuals with chronic hepatitis B virus infection (HBV) or previously resolved HBV are at increased risk of HBV exacerbation or reactivation when they receive treatment with anti‐CD20 monoclonal antibodies (against B‐lymphocyte antigen cluster of differentiation 20 [CD20], an activated‐glycosylated phosphoprotein) like rituximab (RTX). The objective of the current study was to evaluate...
BACKGROUND
Stereotactic body radiotherapy (SBRT) is the standard of care for patients with nonoperative, early‐stage non–small cell lung cancer (NSCLC) measuring < 5 cm, but its use among patients with tumors measuring ≥5 cm is considerably less defined, with the existing literature limited to small, single‐institution reports. The current multi‐institutional study reported outcomes evaluating...
BACKGROUND
Latinas have the highest rates of cervical cancer in the United States and the second highest rate of cervical cancer mortality. One factor in the disparity is the relatively low rate of screening for cervical cancer in this population.
METHODS
Eligible women who were out of adherence with cervical cancer screening (>3 years since their last Papanicolaou [Pap] test) were identified...
BACKGROUND
Atypical teratoid rhabdoid tumors (ATRTs) are rare brain tumors that occur primarily in children under the age of 3 years. This report evaluates the treatment approach and survival outcomes in a large cohort of patients treated in the United States.
METHODS
Using the National Cancer Database, the analysis included all ATRT patients aged 0 to 18 years who were diagnosed between 2004 and...
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