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BACKGROUNDOptimal management remains unknown following prostate‐specific antigen (PSA) failure when considering comorbidity and PSA kinetics at recurrence. In order to define randomized controlled trials (RCTs) that can address this issue, this study examined factors associated with the risk of death following PSA failure.
METHODSOf 206 men randomized to RT with or without 6 months of androgen suppression...
BACKGROUNDC‐reactive protein (CRP) has been associated with outcomes in patients with metastatic adenocarcinoma of the prostate. Associations between prostate adenocarcinoma‐specific endpoints and CRP in patients who are treated for localized disease remain unknown.
METHODSIn total, 206 patients who received radiation therapy for adenocarcinoma of the prostate had at least 1 CRP measured in follow‐up...
BACKGROUNDLung cancers in women, in nonsmokers, and in patients with adenocarcinoma from Asia have more prevalent mutations in the epidermal growth factor receptor (EGFR) gene than their counterparts. However, the etiology of EGFR mutations in this population remains unclear. The authors hypothesized that the human papillomavirus (HPV) type 16/18 (HPV16/18) E6 oncoprotein may contribute to EGFR mutations...
BACKGROUNDIn the current study, the authors report the results of 39 patients with mantle cell lymphoma (MCL) who were treated with chemotherapy and high‐dose rituximab‐containing autologous stem cell transplantation (ASCT) during their first disease remission.
METHODSThe median age of the patients was 54 years. At the time of diagnosis, 87% of patients had Ann Arbor stage IV disease, and 77% had...
BACKGROUNDActive surveillance (AS) is an attempt to avoid overtreatment of clinically insignificant prostate cancer (PCa); however, patient selection remains controversial. Multiparametric prostate magnetic resonance imaging (MP‐MRI) may help better select AS candidates.
METHODSWe reviewed a cohort of men who underwent MP‐MRI with MRI/Ultrasound fusion–guided prostate biopsy and selected potential...
BACKGROUNDSurgical resection has been the standard treatment for early stage multiple primary lung cancer (MPLC). However, a significant proportion of patients with MPLC cannot undergo surgery. For this report, the authors explored the role of stereotactic ablative radiotherapy (SABR) for patients with MPLC.
METHODSPatients with MPLC who received SABR (50 grays [Gy] in 4 fractions or 70 Gy in 10...
BACKGROUNDThe presence of Gleason pattern 5 (GP5) at radical prostatectomy (RP) has been associated with worse clinical outcome; however, this pathologic variable has not been assessed in patients receiving salvage radiation therapy (SRT) after a rising prostate‐specific antigen level.
METHODSA total of 575 patients who underwent primary RP for localized prostate cancer and subsequently received...
BACKGROUNDContemporary treatment protocols for adult acute myeloid leukemia (AML) are age‐specific, and older patients are generally treated less intensively than younger patients. However, it remains uncertain whether older but fit patients with AML really need to have their treatment attenuated.
METHODSTo evaluate the contribution of age to outcome for patients with AML receiving intensive chemotherapy,...
BACKGROUNDStudies have shown that skeletal muscle and adipose tissue are linked to overall survival (OS) and progression‐free survival (PFS). Because targeted therapies have improved the outcome in patients with metastatic renal cell carcinoma (mRCC), new prognostic parameters are required. The objective of the current study was to analyze whether body composition parameters play a prognostic role...
BACKGROUNDIn patients with head and neck and esophageal tumors, nutritional status may deteriorate during concurrent chemoradiotherapy (CRT). The aim of this study was to investigate the influence of enteral nutrition enriched with eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on body composition and nutritional and functional status.
METHODSIn a controlled, randomized, prospective,...
BACKGROUNDThe prognosis of patients with gastric cancer with peritoneal metastasis is extremely poor. This phase 2 study evaluated the benefits and tolerability of weekly intravenous and intraperitoneal paclitaxel (PTX) treatment combined with oral S‐1 in patients with gastric cancer who had macroscopic peritoneal metastasis.
METHODSPatients with gastric cancer who had primary tumors with macroscopic...
BACKGROUNDThe fundamental principle of oncologic surgery is the complete resection of malignant cells. However, small tumors are often difficult to find during surgery using conventional techniques. The objectives of this study were to determine if optical imaging, using a contrast agent already approved for other indications, could improve hepatic metastasectomy with curative intent, to optimize...
BACKGROUNDCancer survivors may experience long‐term and late effects from treatment that adversely affect health and limit functioning. Few studies examine lost productivity and disease burden in cancer survivors compared with individuals who have other chronic conditions or by cancer type.
METHODSWe identified 4960 cancer survivors and 64,431 other individuals from the 2008‐2010 Medical Expenditure...
BACKGROUNDMen with high‐risk prostate cancer are often thought to have very poor outcomes in terms of disease control and survival even after definitive treatment. However, results after external beam radiotherapy have improved significantly through dose escalation and the use of androgen deprivation therapy (ADT). This report describes long‐term findings after low‐dose (< 75.6 Gy) or high‐dose...
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