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BACKGROUND
Given the rarity of anal cancer and the technical aspects involved in radiation (RT) planning, the authors conducted a population‐based analysis evaluating the impact of radiation oncology facility volume on overall survival (OS) in patients with squamous cell carcinoma (SCC) of the anal canal.
METHODS
The National Cancer Data Base (NCDB) was queried for patients with SCC of the anal...
BACKGROUND
Despite controversy surrounding its benefit, the use of concomitant chemoradiotherapy (CCRT) in patients with oropharyngeal squamous cell carcinoma (OPSCC) who are aged > 70 years is increasing. However, to the authors' knowledge, few studies to date have compared the outcomes of different systemic treatments in this population.
METHODS
Records from 74 patients aged ≥ 70 years with...
The treatment of locally advanced rectal cancer (LARC) has benefited from improved surgical techniques and from the implementation of neoadjuvant chemoradiotherapy (CRT), which have markedly decreased the rates of local recurrence. However, distant metastatic disease remains the most significant cause of death for these patients. Although adjuvant chemotherapy (ChT) after neoadjuvant CRT and definitive...
BACKGROUND
Single‐modality radiotherapy is considered a standard‐of‐care option for certain stage III, T1‐2N1 head and neck squamous cell carcinomas (HNSCCs). The role of concomitant chemoradiation is not well established because there have been no studies comparing chemoradiation with radiation alone in this population.
METHODS
This study analyzed patients in the National Cancer Data Base with...
BACKGROUND
Extranodal (or extracapsular) extension (ENE) is an adverse prognostic factor in patients with head and neck cancers who undergo primary surgery. However, the significance of ENE in human papillomavirus (HPV)‐positive oropharyngeal squamous cell carcinoma (OPSCC) is not well established, and single‐institution studies have not established that ENE predicts inferior outcome. The authors...
BACKGROUND
The role of chemoradiotherapy (CRT) in locally advanced pancreatic cancer (LAPC) is uncertain after multiple randomized clinical trials have yielded mixed results. The authors used the National Cancer Data Base (NCDB) to determine whether CRT yields a survival benefit compared with chemotherapy alone (CT).
METHODS
Patients with nonmetastatic LAPC diagnosed during 2004 through 2014 were...
BACKGROUND
The treatment of head and neck cancers is complex and associated with significant morbidity, requiring multidisciplinary care and physician expertise. Thus, facility characteristics, such as clinical volume and academic status, may influence outcomes.
METHODS
The current study included 46,567 patients taken from the National Cancer Data Base who were diagnosed with locally advanced invasive...
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