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BACKGROUND
This study investigated cost‐related medication nonadherence among survivors of adolescent and young adult cancer and a comparison group in the United States.
METHODS
A cross‐sectional analysis of the 2013 to 2015 National Health Interview Survey was performed. N=953 patients who were diagnosed with cancer between the ages of 15 and 39 years were identified, and a comparison group was...
BACKGROUND
KIT‐directed tyrosine kinase inhibitors such as imatinib have demonstrated benefits in KIT‐mutant (KIT+) mucosal, acral, vulvovaginal, and chronically sun‐damaged (CSD) melanoma. Dasatinib has superior preclinical activity in comparison with other tyrosine kinase inhibitors against cells with the most common KIT mutation, exon 11L576P. The ECOG‐ACRIN E2607 trial assessed dasatinib in patients...
BACKGROUND
The ICON6 trial showed that cediranib, an oral inhibitor of vascular endothelial growth factor receptors 1, 2, and 3, improved clinical outcomes for patients with platinum‐sensitive relapsed ovarian cancer when it was used with chemotherapy and was continued as maintenance therapy. This study describes health‐related quality of life (QOL) during the first year of treatment.
METHODS
Four...
BACKGROUND
Adherence to evidence‐based treatment guidelines has been proposed as a measure of cancer care quality. The objective of this study was to determine the rate and predictors of care that does not adhere to National Comprehensive Cancer Network guidelines regarding commencing postoperative radiation therapy (PORT) within 6 weeks of surgery for patients with head and neck squamous cell carcinoma...
BACKGROUND
Breast cancer survivors face a risk of disease recurrence and a higher risk of developing comorbidities such as cardiovascular disease when compared with the general population. Physical activity (PA) has been shown to reduce such risks. The current analyses sought to identify: 1) unique patterns of PA among breast cancer survivors; and 2) characteristics associated with the level of PA...
BACKGROUND
Patients with carcinoid tumors frequently could benefit from the pharmacologic treatment of depression and anxiety. However, many prescribers avoid serotonergic medications due to the theoretical risk of exacerbating carcinoid syndrome.
METHODS
The authors conducted a retrospective chart review of patients with carcinoid tumors and elevated serotonin levels (as measured by 24‐hour urine...
BACKGROUND
Allogeneic hematopoietic stem cell transplantation (allo‐HSCT) is the only treatment with a curative potential for myelodysplastic syndrome (MDS) patients. Allo‐HSCT has substantial risks, particularly in the elderly, and its role for older MDS patients has yet to be defined.
METHODS
We analyzed 88 MDS patients aged ≥ 60 years with allo‐HSCT after reduced intensity conditioning regimens...
BACKGROUND
The objective of the current study was to examine social functioning among adolescents and young adults (AYAs) within the first 2 years after a cancer diagnosis and compare their scores with population norms and identify trajectories of social functioning over time and its correlates.
METHODS
A multicenter, longitudinal study was conducted among 215 AYA patients with cancer aged 14 to...
BACKGROUND
Colorectal cancer (CRC) is the second most commonly diagnosed cancer among Korean American men and women. Although CRC screening is effective in reducing the burden of this disease, studies have shown that Korean Americans have low screening rates.
METHODS
The authors conducted a 2‐arm cluster randomized controlled trial comparing a brochure (print) with a brochure and lay health educator...
BACKGROUND
Women diagnosed with lobular carcinoma in situ (LCIS) have a 3‐fold to 10‐fold increased risk of developing invasive breast cancer. The objective of this study was to evaluate the life expectancy (LE) and differences in survival offered by active surveillance, risk‐reducing chemoprevention, and bilateral prophylactic mastectomy among women with LCIS.
METHODS
A Markov simulation model...
BACKGROUND
Few studies have prospectively examined the relationship between vitamin D status and prostate cancer risk in black men, a group at high risk for both low vitamin D status and prostate cancer.
METHODS
Among black men in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial, we identified 226 prostate cancer cases and 452 controls matched on age at randomization (±5 years),...
BACKGROUND
Early‐stage and intermediate‐stage nasopharyngeal cancer (NPC) generally carry a good prognosis, but for patients with recurrent, metastatic disease, options are limited. In the current study, the authors present a phase 1/2 study to evaluate the efficacy of Epstein‐Barr virus (EBV)‐stimulated cytotoxic T‐lymphocyte (EBV‐CTL) immunotherapy in this patient population.
METHODS
Screening...
BACKGROUND
To the authors' knowledge, no studies to date have explored familial risks of nasopharyngeal carcinoma (NPC) in detail and quantified its lifetime risk in high‐incidence populations.
METHODS
The authors conducted a population‐based case‐control study of 2499 NPC cases and 2576 controls randomly selected in southern China from 2010 through 2014. Unconditional logistic regression was used...
BACKGROUND
Allogeneic hematopoietic cell transplantation (HCT) is a curative therapy for patients with acute myeloid leukemia (AML). However, post‐HCT relapse and regimen‐related toxicity remain significant barriers to long‐term survival. In recent years, new conditioning regimens have been explored to improve transplantation outcomes in patients with AML. Treosulfan combines a potent immunosuppressive...
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