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BACKGROUND
Patients with human papillomavirus (HPV)‐related oropharyngeal cancer (OPC) have improved survival when compared with those with HPV‐negative OPC. Unfortunately, the American Joint Committee on Cancer seventh edition (AJCC‐7ed) staging system does not account for the prognostic advantage observed with HPV‐positive OPC. The purpose of the current study was to validate and compare 2 recently...
Because there is no screening test for ovarian cancer, effective prevention strategies may be the best way to reduce the mortality of this most lethal gynecologic malignancy. Increasing evidence supports the hypothesis that the fallopian tube is the site of origin for the vast majority of high‐grade serous carcinomas. Our growing understanding of the pathogenesis of this disease offers a rare opportunity...
BACKGROUND
There is significant need for quality follow‐up care to optimize long‐term outcomes for the growing population of lower gastrointestinal (GI) cancer survivors. Patient‐reported outcomes (PROs) provide valuable information regarding late and long‐term effects (LLTEs).
METHODS
A convenience sample from 1129 colon, rectal, and anal cancer survivors (n = 792; 218, and 119, respectively)...
BACKGROUND
The objective of this study was to determine the cost‐effectiveness of radical hysterectomy (RH) and sentinel lymph node biopsy (SLNB) for the management of early‐stage cervical cancer (stage IA2‐IB1).
METHODS
A simple decision tree model was developed to follow a simulated cohort of patients with early‐stage cervical cancer treated with RH and 1 of 3 lymph node assessment strategies:...
BACKGROUND
To evaluate the impact of depression before autologous and allogeneic hematopoietic cell transplantation (HCT) on clinical outcomes post‐transplantation.
METHODS
We analyzed data from the Center for International Blood and Marrow Transplant Research to compare outcomes after autologous (n = 3786) or allogeneic (n = 7433) HCT for adult patients with hematologic malignancies with an existing...
BACKGROUND
Overall survival (OS) is considered the gold standard for determining treatment efficacy in oncology trials, but the relation between treatment and OS can be challenging to assess because of long study durations and the impact of subsequent therapies on outcome. Using OS can be particularly difficult for new therapies in hematologic malignancies (HMs).
METHODS
This retrospective analysis...
BACKGROUND
Patient‐reported outcomes (PROs) are increasingly used in clinical settings. Prior research suggests that PROs collected at baseline may be associated with cancer survival, but most of those studies were conducted in patients with breast or lung cancer. The objective of this study was to determine the correlation between prospectively collected PROs and cancer‐specific outcomes in patients...
BACKGROUND
Significant controversy exists as to which treatment modality is most effective for small, solitary hepatocellular carcinomas (HCCs): radiofrequency ablation (RFA), surgical resection (RXN), or transplantation (TXP). Size cutoff values ranging from 20 to 50 mm have been proposed to achieve complete ablation. The current study compares outcomes between RFA, RXN, and TXP as first‐line therapy...
BACKGROUND
We recently reported that peroxisome proliferator‐activated receptor γ agonists target chronic myeloid leukemia (CML) quiescent stem cells in vitro by decreasing transcription of STAT5. Here in the ACTIM phase 2 clinical trial, we asked whether pioglitazone add‐on therapy to imatinib would impact CML residual disease, as assessed by BCR‐ABL1 transcript quantification.
METHODS
CML patients...
BACKGROUND
The use of posttransplant cyclophosphamide (PT‐Cy) has contributed significantly to the success of haploidentical hematopoietic cell transplantation (HCT). Furthermore, several studies have shown promising results in the human leukocyte antigen–matched setting. However, the use of high‐dose cyclophosphamide has been associated with the development of cardiomyopathy. There is a paucity...
BACKGROUND
Patient‐reported outcomes (PROs) (eg, symptoms, functioning) can inform patient management. However, patients and clinicians often have difficulty interpreting score meaning. The authors tested approaches for presenting PRO data to improve interpretability.
METHODS
This mixed‐methods study included an Internet survey of cancer patients/survivors, oncology clinicians, and PRO researchers...
BACKGROUND
Risk factors for impairment in psychosexual development and satisfaction among adult survivors of childhood cancer are poorly understood. The authors compared psychosexual outcomes between survivors and healthy controls, and tested whether at‐risk survivors can be identified by 1) treatment neurotoxicity or 2) diagnosis.
METHODS
A total of 144 young adult survivors of childhood cancer...
BACKGROUND
Prior studies examining the value of lymph node (LN) dissection (LND) in patients with urothelial carcinoma of the upper urinary tract (UTUC) have produced conflicting results. The objective of the current study was to assess the relationship between LN yield and survival among patients undergoing radical nephroureterectomy (RNU).
METHODS
The National Cancer Data Base was used to identify...
BACKGROUND
The purpose of this study was to describe the 30‐day incidence of complications after total laryngectomy (TL) in a high‐volume institution and their impact on the hospital length of stay (LOS) and readmission rates.
METHODS
A retrospective cohort study of all patients who underwent TL at The University of Texas MD Anderson Cancer Center from January 1, 2010 through June 30, 2013 was...
BACKGROUND
The incidence of human papillomavirus (HPV)‐associated (HPV‐positive) head and neck squamous cell carcinoma (HNSCC) of the oropharynx has dramatically increased over the last decade and continues to rise. Newly diagnosed HPV‐positive HNSCCs in the United States currently outnumber any other HPV‐associated cancers, including cervical cancer. Despite introduction of the HPV vaccine, the...
Myelosysplastic syndromes (MDS) include a heterogeneous group of clonal myeloid neoplasms characterized by ineffective hematopoiesis leading to blood cytopenias and a variable risk of progression into acute myeloid leukemia (AML). Although the hypomethylating agent azacitidine prolongs survival among patients with higher risk (HR)‐MDS compared with conventional care, no drug has been shown conclusively...
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