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BACKGROUNDThe functions of cytoskeleton‐associated membrane protein 4 (CKAP4), one kind of type II transmembrane protein, are associated with the palmitoyl acyltransferase DHHC2. The objective of the current study was to investigate CKAP4/DHHC2 expression and its prognostic significance in patients with hepatocellular carcinoma (HCC).
METHODSTwo independent cohorts of 416 patients with HCC were enrolled...
BACKGROUNDThe delivery of urologic oncology care is susceptible to regional variation. In the current study, the authors sought to define patterns of care for patients undergoing genitourinary cancer surgery to identify underserved areas for urologic cancer care in Washington State.
METHODSThe authors accessed the Washington State Comprehensive Hospital Abstract Reporting System from 2003 through...
BACKGROUNDA high frequency of hypogonadism has been reported in male patients with advanced cancer. The current study was performed to evaluate the association between low testosterone levels, symptom burden, and survival in male patients with cancer.
METHODSOf 131 consecutive male patients with cancer, 119 (91%) had an endocrine evaluation of total (TT), free (FT), and bioavailable testosterone...
BACKGROUNDThe current study was performed to evaluate the safety and effectiveness of irradiation with carbon ions using raster scanning as well as prognostic factors in patients with skull base chondrosarcomas.
METHODSBetween 1998 and 2008, 79 patients with chondrosarcoma of the skull base were treated using carbon ions in raster scanning. The applied median total dose was 60 gray equivalent (GyE)...
BACKGROUNDBreakpoint cluster region‐Abelson murine leukemia viral oncogene homolog 1 (BCR‐ABL1) tyrosine kinase inhibitors (TKIs) improve the outcome of patients with childhood Philadelphia chromosome (Ph)‐positive acute lymphoblastic leukemia (ALL) when they are incorporated into postremission induction chemotherapy. To date, no data are available on the impact of TKIs on minimal residual disease...
BACKGROUNDLymph node extracapsular extension (ECE) is a known adverse prognostic factor in head and neck cancer and is an indication for adjuvant chemoradiation (CRT). However, the extent of ECE may provide additional prognostic information in the setting of adjuvant CRT.
METHODSThis study included 350 patients with oral cavity cancer (72.6%) or bulky/nonfunctional laryngeal cancer (27.4%) who underwent...
The discovery that the human papilloma virus (HPV) is associated with a high and increasing percentage of oropharyngeal squamous cell carcinomas (SCCs) is among the most significant advances in the field of head and neck oncology. HPV‐positive oropharyngeal cancer (HPVOPC) has clinical, etiologic, pathologic, and molecular features that distinguish it from HPV‐negative disease. Increasingly, HPVOPC...
BACKGROUNDProstate‐specific antigen (PSA) screening for prostate cancer remains controversial. Most groups recommend informed decision making for men with 10 years of remaining life expectancy. The primary objective of this observational cohort study was to investigate the association between predicted 9‐year mortality and prostate cancer screening among American men aged ≥65 years in 2005 and 2010...
BACKGROUNDFew studies have examined the relationship of lifestyle factors with mortality among patients with colorectal cancer.
METHODSAmong NIH‐AARP Diet and Health study participants, 4213 colon and 1514 rectal cancer cases were identified through linkage to state cancer registries and determined date and cause of death using the National Death Index. Lifestyle factors were assessed at baseline...
BACKGROUNDSurvivors of head and neck squamous cell carcinoma (HNSCC) face excess mortality from multiple causes.
METHODSWe used the population‐based Surveillance, Epidemiology, and End Results (SEER) cancer registry data to evaluate the causes of death in patients with nonmetastatic HNSCC diagnosed between 1992 and 2005 who survived at least 3 years from diagnosis (long‐term survivors). We used competing‐risks...
BACKGROUNDIntegration of mutational profiling to identify driver genetic alterations in a clinical setting is necessary to facilitate personalized lung cancer medicine. A tumor genotyping panel was developed and the Shizuoka Lung Cancer Mutation Study was initiated as a prospective tumor genotyping study. This study reports the frequency of driver genetic alterations in Japanese lung adenocarcinoma...
BACKGROUNDThe evidence regarding correlations between various anthropometric characteristics and breast cancer risk among young women is mixed, and few studies have assessed these associations by subtype.
METHODSThis was a population‐based, case‐control study of 779 women with estrogen receptor (ER)‐positive breast cancer; 182 women with ER‐negative/human epidermal growth factor‐2 (HER2)‐negative/progesterone...
BACKGROUNDEarly identification of mutations may guide patients with metastatic colorectal cancer toward targeted therapies that may be life prolonging. The authors assessed tumor genotype correlations with clinical characteristics to determine whether mutational profiling can account for clinical similarities, differences, and outcomes.
METHODSUnder Institutional Review Board approval, 222 patients...
BACKGROUNDTo the authors' knowledge, only limited data are available regarding the quality of end‐of‐life care for patients with hematologic malignancies. In this retrospective cohort study, the quality of end‐of‐life care was compared between patients with hematologic malignancies and those with solid tumors.
METHODSAll adult patients who died of advanced cancer between September 1, 2009 and February...
BACKGROUNDTo the authors' knowledge, it remains unknown whether race‐based differences in cancer outcomes have changed with time. In the current study, the authors assessed whether racial disparities in cancer‐specific mortality have improved over the last 20 years.
METHODSThe Surveillance, Epidemiology, and End Results program was used to identify 2,713,474 patients diagnosed between 1988 and 2007...
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