The interrelation between TSH, thyroid hormones and metabolic parameters is complex and has not been confirmed. This study aimed to determine the association of TSH and thyroid hormones in euthyroid subjects and the relationship between thyroid function and metabolic risk factors. Furthermore, this study examined whether thyroid function has predictive power for metabolic syndrome.
This study evaluated an association between testosterone, sex hormone‐binding globulin (SHBG) and metabolic syndrome (MetS).We also evaluated the genetic and environmental influences on the association.
A total of 1098 Korean adult men including 139 monozygotic twin pairs.
Main Outcome Measure
MetS was defined...
Turner syndrome (TS) is associated with a variety of morbidities affecting nearly every body system, some of which increase in prevalence in adult life. The severity of clinical features in TS is roughly in parallel with the magnitude of the deficit of X‐chromosome material. The aim of this study was to extend the established karyotype‐phenotype relationships using data from a large...
Male ageing is associated with lower circulating testosterone (T) and increased incidence of cardiovascular disease (CVD). Whether physical activity (PA) interacts with hormones to modify CVD risk is unclear.
We assessed whether PA and sex hormone concentrations were independently associated with measures of CVD risk.
A total of 1649 men.
Background and Objective
Polycystic ovary syndrome (PCOS) is a common heterogeneous endocrine disorder associated with metabolic syndrome (MetS). The aim of this systematic review and meta‐analysis was to provide the most reliable estimate risk of MetS in women with PCOS, compared to healthy controls.
A comprehensive literature search was performed in PubMed [including Medline], Web of...
Thyroid hormones (THs) are primarily responsible for the regulation of energy homeostasis and metabolism. However, few prospective studies have assessed the association between THs and metabolic syndrome (MetS) in a general population. We therefore designed a cohort study to examine whether serum TH levels within the reference range are predictive factors for developing MetS in adults....
Although metabolic syndrome has been studied in patients with autonomous cortisol secretion, there are limited data for those with nonfunctioning adrenal incidentaloma (NFAI).
To assess metabolic syndrome frequency in NFAI patients and controls without adrenal adenoma according to World Health Organization (WHO), National Cholesterol Education Program‐Adult Treatment Panel III...
Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathies affecting reproductive‐aged women with adverse reproductive, metabolic and psychological outcomes. It has a complex pathophysiology and therefore requires a multidiscipline clinical approach. However, there remains limited research synthesizing the broad clinical implications of PCOS which would assist clinicians...
To investigate both independent and combined effects of insulin resistance and β‐cell dysfunction on cardio‐metabolic abnormalities in polycystic ovary syndrome (PCOS).
A national epidemiologic survey was performed in reproductive aged females in China from October 2007 to September 2011.
A total of 824 PCOS and 2715 non‐PCOS were included. The Rotterdam Criteria were...
Low endogenous sex hormones and low physical activity (PA) levels have been associated with CVD risk. Whether these interact to influence CVD outcomes remains unclear. We assessed whether sex hormone concentrations and PA were additively associated with lower central adiposity and CVD risk.
3351 community‐dwelling men, mean age 77 years.
Baseline testosterone (T),...
Familial partial lipodystrophy type 2 (FPLD2) is characterized by insulin resistance, adipose atrophy of the extremities and central obesity. Due to the resemblance with Cushing's syndrome, we hypothesized a putative role of glucocorticoid in the pathogenesis of metabolic abnormalities in FPLD2.
To evaluate the phenotypic heterogeneity and glucocorticoid sensitivity in FPLD2 patients...
Polycystic ovarian syndrome (PCOS) is a heterogeneous endocrine disorder associated with mitochondrial dysfunction and insulin resistance (IR). MOTS‐c, a mitochondrial peptide, promotes insulin sensitivity (IS) through activating AKT and AMPK‐dependent pathways. The current study was designed to examine the response of MOTS‐c to lipids (intralipid) followed by insulin in PCOS and healthy...
To investigate whether maternal blood pressure (BP) below the diagnostic criteria of hypertensive disorders of pregnancy (HDP) is associated with maternal BP 5 years later.
Prospective, observational study.
Dublin, Ireland (2007‐2011).
Three hundred twenty‐nine women from the ROLO study (Randomized cOntrol trial of LOw glycaemic index diet to prevent the recurrence...
Existing data are contradictory on the prevalence of polycystic ovary syndrome (PCOS) and metabolic syndrome (MetS) in women with severe obesity (body mass index [BMI] ≥ 35 kg/m2), and there are few studies investigating the effect of weight reduction in women with severe obesity and PCOS. The aim was to study the prevalence of PCOS and MetS among women with severe obesity and to evaluate...
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