Hypophosphatasia (HPP) is a rare skeletal disease characterized by hypomineralization and low alkaline phosphatase activity. Asfotase alfa (AA) has been recently developed to treat HPP complications. This study evaluated its safety and efficacy in Japan.
Open‐label, multicentre, prospective trial. Patients were enrolled in 11 hospitals from June 2014 to July 2015.
There is debate whether hemithyroidectomy is sufficient for patients with papillary thyroid cancer (PTC) sized 1‐4 cm. Therefore, we investigated whether hemithyroidectomy affects recurrence rate compared with thyroidectomy in patients with PTC sized 1‐4 cm.
Retrospective observational study.
We included 147 patients with 1‐4 cm PTC who underwent hemithyroidectomy between...
Hypophosphataemic rickets (HR) is a group of rare hereditary renal phosphate wasting disorders caused by mutations in PHEX, FGF23, DMP1, ENPP1, CLCN5 or SLC34A3.
To investigate underlying genetic defects in patients with hypophosphataemic rickets.
We analysed genomic DNA from nine unrelated families for mutations in the entire coding region of PHEX, FGF23, DMP1, ENPP1, CLCN5...
Male performance in athletic events begins to exceed that of age‐matched females during early adolescence, but the timing of this divergence relative to the onset of male puberty and the rise in circulating testosterone remains poorly defined.
This study is a secondary quantitative analysis of four published sources which aimed to define the timing of the gender divergence in...
Dyslipidaemia is common in patients with subclinical hypothyroidism (SCH). To date, there is no universal agreement regarding the lipid‐lowering effect of substitution treatment with L‐T4 in patients with SCH. We aimed to clarify the effect by conducting this systematic review and meta‐analysis of randomized controlled trials (RCTs).
We systematically searched PubMed, the Cochrane...
An inhibitory effect of ghrelin on gonadotrophin secretion has been reported in normally menstruating women possibly modulated by endogenous oestrogen. The aim of this study was to examine the effect of ghrelin on gonadotrophin and prolactin (PRL) secretion in oestrogen‐deprived postmenopausal women.
Prospective intervention study.
Patients and Measurements
Ten healthy postmenopausal...
Observational studies have suggested positive associations between serum 25‐hydroxyvitamin D (25(OH)D) levels and muscular strength, balance and quality of life. Our aim was to examine whether high‐dose vitamin D supplementation would improve these measures as compared to standard‐dose vitamin D, as well as the possible muscular effects of single nucleotide polymorphisms (SNPs) in genes...
The length of the CAG repeats in exon 1 of the androgen receptor (AR) gene has been shown to be inversely correlated with AR transcriptional activity. This study aimed to investigate the correlations between the length of CAG repeat in AR and serum lipids and hypertension in Chinese men.
Design and patients
The relationship between length of the CAG repeat in exon 1 of AR with prevalence...
We assessed the associations between FDG uptake in primary papillary thyroid carcinomas (PTCs) and clinicopathological features, including the BRAF V600E mutation, using quantitative and qualitative analyses of preoperative PET/CT data.
Design and Patients
This was a retrospective review of 106 patients with PTC who underwent PET/CT scans between February 2009 and January 2011 before...
This study was designed to evaluate the effects of the dietary approaches to stop hypertension (DASH diet) on weight loss, anti‐Müllerian hormone (AMH) and metabolic profiles in women with polycystic ovary syndrome (PCOS).
Design, Patients and Measurements:
A randomized controlled clinical trial was conducted among 60 overweight or obese patients with PCOS. Patients were randomly assigned...
To determine whether an overnight metyrapone test (OMT) within the first week postpituitary surgery can definitively assess the hypothalamic‐pituitary‐adrenal (HPA) axis, compared with subsequent dynamic tests and glucocorticoid requirement at 6 months.
Prospective study measuring morning cortisol levels on days 3 and 4 post‐operatively, OMT day 5‐7 and week 6, week 6 250 μg short...
The interrelation between TSH, thyroid hormones and metabolic parameters is complex and has not been confirmed. This study aimed to determine the association of TSH and thyroid hormones in euthyroid subjects and the relationship between thyroid function and metabolic risk factors. Furthermore, this study examined whether thyroid function has predictive power for metabolic syndrome.
Normal or elevated 24‐hour urinary calcium (Ca) excretion is a diagnostic marker in primary hyperparathyroidism (PHPT). It is used to distinguish familial hypocalciuric hypercalcaemia (FHH) from PHPT by calculating the Ca/creatinine clearance ratio (CCCR). The variance of CCCR in patients with PHPT is considerable. The aim of this study was to analyse the parameters affecting CCCR in patients...
Serum sex steroid concentrations may alter body composition and glucose homoeostasis in men in a dose‐response manner. We evaluated these end‐points in healthy men rendered medically castrate through use of a gonadotrophin‐releasing hormone antagonist (acyline) with incremental doses of exogenous testosterone (T) gel.
Subjects (n=6‐9 per group) were randomly assigned to injections...
Increased fracture rates are observed in renal transplant recipients (RTRs) compared with the general population. Risk factors include age, diabetes, dialysis vintage, immunosuppression and mineral and bone disorders.1 Low serum phosphorus levels occur post‐transplantation; however, its relationship with fracture risk has not been evaluated. The purpose of this study was to evaluate risk...
The cover image, by J. Schaefers et al., is based on the Original Article Clinical presentation and outcome of children with central diabetes insipidus associated with a self‐limited or transient pituitary stalk thickening, diagnosed as infundibuloneurohypophysitis, DOI: 10.1111/cen.13362.
Differentiated thyroid cancer (DTC) is the most common malignancy of the endocrine system. There has been a significant increase in its incidence over the past two decades attributable mainly to the use of more sensitive diagnostic modalities. Ultrasound‐guided fine needle aspiration cytology is the mainstay of diagnosis of benign disorders and malignancy. However, approximately 20% of lesions cannot...
The objective of this study was to evaluate the association of urine clusterin/apolipoprotein J (Apo J) with the development and/or progression of diabetic kidney disease (DKD) in type 2 diabetes.
Materials and Methods
A total of 159 type 2 diabetic patients and 20 nondiabetic subjects with estimated glomerular filtration rate (eGFR) ≥60 mL/min/1.73 m2 were enrolled. The baseline values...
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