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Objective
A novel 99mTc‐tricine‐EDDA‐Hynic‐c‐Met molecular probe was synthetized, and nude mice models of human non‐small‐cell lung cancer (NSCLC) were established in order to preliminarily investigate that whether the molecular probe can be used to screen c‐Met inhibitor for targeted drug therapy in NSCLC.
Methods
With Hynic as the chelating agent, 99mTcO4‐labeled c‐Met receptor was used to synthetize...
11h is a very potent inhibitor against epidermal growth factor receptor triple mutation L858R/T790M/C797S (EGFRTM) with 13‐fold stronger potency than the FDA‐approved osimertinib. Recently, two new EGFRTM inhibitors, 11d and 11e, were reported which revealed 2.8‐ and 2.3‐fold stronger potency than 11h, respectively. 11h, 11d, and 11e have the same structures but differ only in their aliphatic chain...
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