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A bisoxyphenylene‐bisbenzimidazole series with increasing aliphatic chain length (CH2 to C10H20) containing a meta‐ (m) or para (p)‐benzimidazole linkage to the phenylene ring was tested for ability to inhibit the growth of metronidazole‐susceptible (C1) and metronidazole‐refractory (085) Trichomonas vaginalis isolates under aerobic and anaerobic conditions. Compound 3m, 2,2′‐[α,ω‐propanediylbis(oxy‐1,3‐phenylene)]bis‐1...
Trichomonas vaginalis causes trichomoniasis, a neglected sexually transmitted disease. Due to severe health consequences and treatment failure, new therapeutic alternatives are crucial. Phloroglucinols from southern Brazilian Hypericum species demonstrated anti‐T. vaginalis and anti‐Leishmania amazonensis activities. The modulation of biochemical pathways involved in the control of inflammatory response...
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