The detection in high‐performance liquid chromatography (HPLC) systems devoted to food analysis is usually carried out using spectrophotometric UV–visible (UV–vis) or mass spectrometry (MS) detectors. This chapter deals with the design and integration of electrochemical detectors, namely the amperometric, coulometric, and voltammetric ones, within the HPLC separation system and their compatibility and compromise with the chromatographic conditions necessary to achieve optimum resolution of the analytes in food and agricultural analysis. Liquid mercury has always been a common electrode material, especially in the form of the dropping mercury electrode, used in HPLC‐ED for monitoring electrochemical reduction because of its extended negative potential window. In the chapter, a list of selected applications developed in the late years regarding ED in HPLC for the analysis of food products is reported and commented. HPLC‐ED is well accepted in the analysis of carbohydrate and natural polyphenols in beverages and food commodities.