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Na+/K+‐ATPase, a transmembrane protein essential for maintaining the electrochemical gradient across the plasma membrane, acts as a receptor for cardiotonic steroids such as ouabain. Cardiotonic steroids binding to Na+/K+‐ATPase triggers signalling pathways or inhibits Na+/K+‐ATPas activity in a concentration‐dependent manner, resulting in a modulation of Ca2+ levels, which are essential for homeostasis...
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