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Some matrix chemicals used in MALDI mass spectrometry are not sufficiently vacuum‐stable and therefore not suitable for extended MALDI imaging experiments. Caging the MALDI matrices by covalent attachment of a photocleavable group renders them vacuum‐stable, as reported by Qiuqin Zhou et al. in their Research Article (e202217047). The caged matrix is eventually uncaged in situ by the UV laser in the...
Insufficient vacuum stability of matrix chemicals is a major limitation in matrix‐assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI) of large tissue sample cohorts. Here, we designed and synthesized the photo‐cleavable caged molecule 4,5‐dimethoxy‐2‐nitrobenzyl‐2,5‐dihydroxyacetophenone (DMNB‐2,5‐DHAP) and employed it for lipid MALDI‐MSI of mouse brain tissue sections. DMNB‐2,5‐DHAP...
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