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1,5‐Disubstituierte 1,2,3‐Triazole können als Mimetika von Disulfidbindungen genutzt werden. Wie T. Durek, D. J. Craik und Mitarbeiter in ihrer Zuschrift auf S. 11369 demonstrieren, kann das Triazol‐Motiv in cyclische Peptide basierend auf dem Sonnenblumen‐Trypsininhibitor‐1 eingebaut werden. NMR‐ und Röntgenstrukturanalysen zeigen, dass die Triazolbrücke bei gleichbleibender Aktivität eine verbesserte...
Ruthenium‐catalysed azide–alkyne cycloaddition (RuAAC) provides access to 1,5‐disubstituted 1,2,3‐triazole motifs in peptide engineering applications. However, investigation of this motif as a disulfide mimetic in cyclic peptides has been limited, and the structural consequences remain to be studied. We report synthetic strategies to install various triazole linkages into cyclic peptides through backbone...
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