Allergy
Background: This study reports the clinical and immunological state of patients 3 years after a 6‐year period of Xolair treatment for severe allergic asthma.
Methods: The patient’s cat allergen sensitivity, measured as CD‐sens, IgE and IgE‐ and IgG4 antibodies, was analysed and compared with asthma severity evaluated from FEV1 and a questionnaire.
Results: Three years after treatment with Xolair...
Background: Diisocyanate‐induced asthma (DIA) is known to be associated with poor prognosis. We wished to clarify if matrix metalloproteinases (MMP)‐7, ‐8 or ‐9 or tissue inhibitor of matrix metalloproteinases (TIMP‐1) are associated with the functional or inflammatory outcome in DIA patients.
Methods: This is a longitudinal study where 17 patients with DIA diagnosed by a specific challenge test...
Background: Recent data suggest that the previously rising trend in childhood wheezing symptoms has plateaued in some regions. We sought to investigate sex‐specific trends in wheeze, asthma, allergic conditions, allergic sensitization and risk factors for wheeze.
Methods: We compared two population‐based cohorts of 7 to 8‐year olds from the same Swedish towns in 1996 and 2006 using parental expanded...
Background: Esophageal remodeling occurs in eosinophilic esophagitis (EE) patients but whether the components of remodeling in the subepithelium are reversible by administration of topical oral corticosteroids is unknown.
Methods: We quantitated the degree of lamina propria remodeling in esophageal biopsies obtained before and after at least 3 months of therapy with budesonide in 16 pediatric EE...
Background: Genetics of acute allergies has focused on identifying single nucleotide polymorphisms (SNPs) within genes relevant in the pathogenesis. In this study, we begin a systems biology analysis of the interconnectivity and biological functions of these genes, their transcripts and their corresponding proteins.
Methods: The literature (Pubmed) was searched for SNPs within genes relevant in...
Background: L‐selectins on leukocytes and their counter‐receptors on endothelial cells have been shown to be involved in leukocyte recruitment in chronic rhinosinusitis without nasal polyps (NP).
Objectives: The purpose of this study was to evaluate the expression level of functionally active endothelial L‐selectin ligands in NP obtained from patients with NP of different etiology [simple NP, antro‐choanal...
Background: Itch is the major symptom of many allergic diseases; yet it is still difficult to measure objectively. The aim of this study was to use an evaluated itch stimulus model in lesional (LS) and nonlesional (NLS) atopic eczema (AE) skin and to characterize cerebral responses using functional magnetic resonance imaging (fMRI).
Methods: Thermal modulation was performed on a histamine stimulus...
Background: The role of myeloid and plasmacytoid dendritic cells and its consequences for the TH2 skew in chronic rhinosinusitis (CRS) with nasal polyps (CRSNP+) should be detailed.
Methods: In 18 CRS patients without nasal polyps (CRSNP−), 35 CRSNP+ patients and 22 patients with nasal structural abnormalities without rhinosinusitis (controls), dendritic cells (DC) were differentiated into myeloid...
Oral food challenges still remain the gold standard in the diagnosis of food related symptoms and are performed to obtain a clear ‘yes or no’ response. However, this is often difficult to achieve, and so proposals may be appropriate for criteria on when to stop oral food challenges. In daily practice it makes sense to challenge until clear objective symptoms occur without harming the patient. Clinical...
To cite this article: Mattila P, Renkonen J, Toppila‐Salmi S, Parviainen V, Joenväärä S, Alff‐Tuomala S, Nicorici D, Renkonen R. Time‐series nasal epithelial transcriptomics during natural pollen exposure in healthy subjects and allergic patients. Allergy 2010; 65: 175–183.
AbstractBackground: The role of epithelium has recently awakened interest in the studies of type I hypersensitivity.Objective: ...
To cite this article: Contoli M, Bousquet J, Fabbri LM, Magnussen H, Rabe KF, Siafakas NM, Hamid Q, Kraft M. The small airways and distal lung compartment in asthma and COPD: a time for reappraisal. Allergy 2010; 65: 141–151.
AbstractThe involvement of small airways in the pathogenesis of asthma and chronic obstructive pulmonary disease (COPD) has been debated for a long time. However, a proper definition...
To cite this article: Anandan C, Nurmatov U, van Schayck OCP, Sheikh A. Is the prevalence of asthma declining? Systematic review of epidemiological studies. Allergy 2010; 65: 152–167.
AbstractAsthma prevalence has increased very considerably in recent decades such that it is now one of the commonest chronic disorders in the world. Recent evidence from epidemiological studies, however, suggests that...
To cite this article: Capasso M, Varricchio A, Ciprandi G. Impact of allergic rhinitis on asthma in children: effects on bronchodilation test. Allergy 2010; 65: 264–268 DOI: 10.1111/j.1398‐9995.2009.02168.x.
AbstractBackground: Relevant relationship exists between upper and lower airways. Bronchial obstruction is a paramount feature of asthma and its reversibility is considered a diagnostic step...
To cite this article: Candelaria PV, Backer V, Khoo S‐K, Bizzintino JA, Hayden CM, Baynam G, Laing IA, Zhang G, Porsbjerg C, Goldblatt J, LeSouëf PN, The Greenlandic Study Population Group. The importance of environment on respiratory genotype/phenotype relationships in the Inuit. Allergy 2010; 65: 229–237.
AbstractBackground: Genetic and environmental influences and their interactions are central...
To cite this article: Bunyavanich S, Soto‐Quiros ME, Avila L, Laskey D, Senter JM, Celedón JC. Risk factors for allergic rhinitis in Costa Rican children with asthma. Allergy 2010; 65; 256–263 DOI: 10.1111/j.1398‐9995.2009.02159.x.
AbstractBackground: Risk factors for allergic rhinitis (AR) in asthmatics are likely distinct from those for AR or asthma alone. We sought to identify clinical and environmental...