The effect of microstructure on cavitation developed during hot deformation of a fine-grained AA5083 aluminum-magnesium alloy is investigated. Two-point correlation functions and three-dimensional (3-D) microstructure characterization reveal that cavitation depends strongly on the mechanism that controls plastic deformation. Grain-boundary-sliding (GBS) creep produces large, interconnected cavities rapidly during plastic straining. Solute-drag (SD) creep produces isolated cavities with less total volume fraction at a given strain. The 3-D microstructure data reveal adjacency between various microstructural features. Cavities are observed to be preferentially adjacent to large Al6(Mn,Fe) particles and to Mg-Si particles of all observed sizes. These data suggest that cavities preferentially nucleate at Mg-Si particles and at large Al6(Mn,Fe) particles. This result may be applied to reduce cavitation in commercial hot-forming operations utilizing aluminum-magnesium alloys.