Fabrication of multi-material engineering components is one of the technologies to address diverse and conflicting functional requirements posed by rapid technological development. Bi-metallic tube is one such multi-material component with different materials on internal and outer surfaces. This paper briefs about fabrication of a bi-metallic tubular structure with an indigenously developed 3.5 kW CO2 laser integrated with a beam delivery system, a 5-axis CNC work station along with a powder feeding sub-system. The bi-metallic tube was fabricated with cobalt based alloy Stellite 21 on inner diameter and type 316L stainless steel on the outer diameter. Besides, a stainless steel tube with an internal step of Stellite 21 was also fabricated. As-fabricated bi-metallic structure was structurally sound and carried desired transition in chemical composition and hardness across its wall thickness.