In the framework of the BMBF-funded project OrthoMIT a non-active remote pointing device for different purposes in Computer-Assisted Surgery (CAS) has been developed and is currently being evaluated. In the course of integration and interoperability for technical equipment within the operating room (OR) not only new hard- and software inter-faces but also innovative concepts for man-machine-interfaces have to be considered, in order to ease the use and the control process of planning- and navigation systems and their dedicated devices. Furthermore, for safety reasons the new man-machine-interaction concepts have to be integrated in the intraoperative workflow. The new developed multi-purpose Remote-Pointer (RP) combines three different input modalities and allows the usage out of the sterile area. It integrates the function of a conventional tracking probe, enables the operator to control graphical user interfaces (GUI) and offers, with the help of gesture detection, the possibility to handle dialog-based applications. The Remote-Pointer can be used from any position inside the OR, as long as it is located inside the workspace of the tracking camera. In this paper we describe the usability evaluation of the Remote-Pointer in comparison to a conventional mouse and the Logitech AIR-mouse. The focus of the usability investigation is on the performance character of the “mouse emulation” mode of the RP which allows the controlling of a GUI.