This chapter describes why we believe that the technology used in SanssouciDB – our prototype relational database system – is a good fit for Cloud Computing. We begin in Section 8.1 by defining Cloud Computing. In Section 8.2 we describe the different types of applications that are suited for the cloud. Section 8.3 takes a provider’s point of view and describes the type of infrastructure required to offer cloud services. We also examine multi-tenancy, replication, choice of hardware, and energy efficiency. In Section 8.4, we finally offer our conclusions regarding how in-memory computing will play an ever-increasing role in Cloud Computing.