The paper presents results of SIFT (Scale-Invariant Feature Transform) method application to support transbronchial needle-aspiration biopsy. An image generated during a bronchoscopic examination is often disturbed by vomiting reflex of the patient, or by sudden influxes of saliva or mucus. The presented system supporting the doctor is capable of monitoring the examined spot and signalling return to this spot after the disturbance ends or after the repeated examination of the same fragment of bronchial tree. A modified SIFT method is used, with a particular focus on real-time SIFT calculation.