Computed tomography (CT) colonography has been in development for more than a decade, with hundreds of articles now published on its performance and technical capabilities. With the conclusion and publication of the National CT Colonography trial [1] and endorsement of the technique for screening by a multi-society task force (including the American Cancer Society, American College of Radiology, US Multi-society Task Force on Colorectal Cancer) [2], the clinical validation of CT colonography in the prepared colon has been completed. This chapter highlights the most important current issues for CT colonography.