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Objective Atherosclerosis is a chronic inflammatory process. Poly(ADP-ribose) polymerase-1 (PARP), a nuclear enzyme linked to DNA repair, has been shown to be involved in atherogenesis; however, the effects on dendritic cells, T cells and serum auto-antibody levels are not fully understood. Methods Male Apoe-/- mice on a western diet were treated with the PARP inhibitor 1NO-1001 (n = 15), while...
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