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S-adenosyl-l-homocysteine hydrolase of Plasmodium falciparum (PfSAHH) has been reported as a potential drug target against malaria. A series of aristeromycin derivatives and analogs were designed and tested for inhibition of PfSAHH. 2-Fluoroaristeromycin has been reported as a potential inhibitor of PfSAHH. Here, we have performed the molecular dynamics simulation study of 2-Fluoroaristeromycin with...
S-adenosyl-l-homocysteine hydrolase (SAHH) is a ubiquitous enzyme that plays a significant role in methylation-based processes by maintaining the intracellular balance between S-adenosylhomocysteine and S-adenosylmethionine. In the past years, some analogs and derivatives of aristeromycin have been reported as a potential inhibitor of Plasmodium falciparum’s SAHH (PfSAHH), but no effective therapy...
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