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The combination of natural and synthetic polymeric materials grafted hydrogels offer great potential as oral therapeutic systems because of its intrinsic biocompatibility, biodegradability, protect labile drugs from metabolism and controlled release properties. Hence, in the present study, we aimed to prepare and optimize oral delivered pH-responsive Zein-co-acrylic acid hydrogels incorporated with...
α-l-Rhamnosidase may biotransform rutin into isoquercetin with better bioavailability and bioactivity. To date, the high-throughput screening for the activity of α-l-rhamnosidases on rutin could not be achieved. Herein, based on the spectral differences between rutin and its aglycone quercetin in alkaline pH 10.0, we have developed a novel and simple spectrophotometric method for high-throughput screening...
In the present study, four different natural compounds including quercetin, gallic acid, rutin, and lupeol were studied for their anti-leishmanial potentials with anticipated mechanism of action through in vitro and in silico approaches. Results showed that rutin was exceedingly active (IC50; 91.2 µg/ml) against the promastigote form of Leishmania tropica compared to quercetin (IC50; 182.3 µg/ml),...
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