Infectious Agents and Cancer

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Epstein-Barr virus-specific methylation of human genes in gastric cancer cells

Julie L Ryan, Richard J Jones, Shannon C Kenney, Ashley G Rivenbark, more

Infectious Agents and Cancer > 2010 > 5 > 1 > 1-15

Background Epstein-Barr Virus (EBV) is found in 10% of all gastric adenocarcinomas but its role in tumor development and maintenance remains unclear. The objective of this study was to examine EBV-mediated dysregulation of cellular factors implicated in gastric carcinogenesis. Methods Gene expression patterns were examined in EBV-negative and EBV-positive AGS gastric epithelial cells using a low...

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Disruption of Bcl-2 and Bcl-xL by viral proteins as a possible cause of cancer

Kenneth Alibek, Stephanie Irving, Zarina Sautbayeva, Ainur Kakpenova, more

Infectious Agents and Cancer > 2014 > 9 > 1 > 1-13

The Bcl proteins play a critical role in apoptosis, as mutations in family members interfere with normal programmed cell death. Such events can cause cell transformation, potentially leading to cancer. Recent discoveries indicate that some viral proteins interfere with Bcl proteins either directly or indirectly; however, these data have not been systematically described. Some viruses encode proteins...

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The changing pattern of ano-rectal cancer, squamous cell carcinoma of the eye, and Hodgkin’s lymphoma as non-AIDS-defining cancers, by HIV status, in Tanzania over 11 years (2002-2012): a retrospective case-report study

Clare Meernik, Amr S Soliman, Twalib Ngoma, Crispin Kahesa, more

Infectious Agents and Cancer > 2014 > 9 > 1 > 1-8

Background In Tanzania, 5.1% of adults aged 15-49 are infected with HIV. While rates of HIV-related malignancies have declined globally with antiretroviral therapy (ART), including Tanzania, rates of non-AIDS-defining cancers (NADCs) are believed to have increased. Therefore, we determined trends of three NADCs in Tanzania: ano-rectal cancer, squamous cell carcinoma of the eye, and Hodgkin’s lymphoma...

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Correlation of EGFR, pEGFR and p16 ^INK4 expressions and high risk HPV infection in HIV/AIDS-related squamous cell carcinoma of conjunctiva

Anthony Mwololo, Joshua Nyagol, Emily Rogena, Willis Ochuk, more

Infectious Agents and Cancer > 2014 > 9 > 1 > 1-8

Background Squamous cell carcinoma of conjunctiva has increased tenfold in the era of HIV/AIDS. The disease pattern has also changed in Africa, affecting young persons, with peak age-specific incidence of 30-39 years, similar to that of Kaposi sarcoma, a well known HIV/AIDS defining neoplasm. In addition, the disease has assumed more aggressive clinical course. The contributing role of exposure...

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Human Mammary Tumor Virus (HMTV) sequences in human milk

Teiko Nartey, Heberth Moran, Tania Marin, Kathleen F Arcaro, more

Infectious Agents and Cancer > 2014 > 9 > 1 > 1-8

Background Retroviral sequences 90-95% homologous to the mouse mammary tumor virus (MMTV) were present in 38% of the breast cancers studied from American women and were not detectable in non-tumor breast tissue from the same patient. The entire proviral structure was described and viral particles were isolated from primary cultures of human breast cancer. This virus was designated as human mammary...

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Detection of MMTV-Like sequences in Moroccan breast cancer cases

Meriem Slaoui, Mohammed El Mzibri, Rachid Razine, Zineb Qmichou, more

Infectious Agents and Cancer > 2014 > 9 > 1 > 1-7

Introduction The mouse mammary tumor virus (MMTV) like sequences have been reported to be present in some human breast cancers, but their association with breast cancer development is still controversial. Methods In this retrospective study, we investigated the status of MMTV-like in 42 tumor biopsies and 18 paired normal tissues from Moroccan patients with breast cancer. MMTV-like...

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Risk factors for cervical HPV infection and genotypes distribution in HIV-infected South Brazilian women

Sheila C Rocha-Brischiliari, Fabrícia Gimenes, André L P de Abreu, Mary M T Irie, more

Infectious Agents and Cancer > 2014 > 9 > 1 > 1-6

Background Human Papillomavirus (HPV) infection is particularly burdensome for women infected with human immunodeficiency virus (HIV), which increases their risk of developing cervical lesions and cancer (CC). We conducted a molecular study of the distribution of cervical HPV genotypes and the risk factors for this infection in HIV-infected Brazilian women. Findings...

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HIV-1 Tat induces DNMT over-expression through microRNA dysregulation in HIV-related non Hodgkin lymphomas

Anna Luzzi, Federica Morettini, Sara Gazaneo, Lucia Mundo, more

Infectious Agents and Cancer > 2014 > 9 > 1 > 1-18

Background A close association between HIV infection and the development of cancer exists. Although the advent of highly active antiretroviral therapy has changed the epidemiology of AIDS-associated malignancies, a better understanding on how HIV can induce malignant transformation will help the development of novel therapeutic agents. Methods HIV has been reported to induce the...

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Prevalence of HPV infection and other risk factors in a Fijian population

Sunia Foliaki, Naomi Brewer, Neil Pearce, Peter Jf Snijders, more

Infectious Agents and Cancer > 2014 > 9 > 1 > 1-8

Background Cancer is among the leading contributors to morbidity and mortality in the Pacific, but the magnitude of the problem and the potential for prevention have not been comprehensively studied. Over the past decade, cervical cancer has been the most common cancer among women in Fiji with an age standardised cervical cancer incidence rate of 51 per 100,000. This rate is among the highest...

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The GH-IGF-SST system in hepatocellular carcinoma: biological and molecular pathogenetic mechanisms and therapeutic targets

Claudia Pivonello, Maria Cristina De Martino, Mariarosaria Negri, Gaia Cuomo, more

Infectious Agents and Cancer > 2014 > 9 > 1 > 1-23

Hepatocellular carcinoma (HCC) is the sixth most common malignancy worldwide. Different signalling pathways have been identified to be implicated in the pathogenesis of HCC; among these, GH, IGF and somatostatin (SST) pathways have emerged as some of the major pathways implicated in the development of HCC. Physiologically, GH-IGF-SST system plays a crucial role in liver growth and development since...

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Prevalence and risk factors for High-Risk Human Papillomavirus (hrHPV) infection among HIV-infected and Uninfected Rwandan women: implications for hrHPV-based screening in Rwanda

Jean d’Amour Sinayobye, Marc Sklar, Donald R Hoover, Qiuhu Shi, more

Infectious Agents and Cancer > 2014 > 9 > 1 > 1-11

Background New World Health Organization guidelines recommend high-risk human papillomavirus (hrHPV) screen-and-treat strategies for cervical cancer prevention. We describe risk of, and risk factors for, testing hrHPV positive in a pilot study of hrHPV screen-and-treat conducted in Rwanda. Methods A total of 2,964 women, 1,289 HIV-infected (HIV [+]) and 1,675 HIV-uninfected (HIV [-]),...

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Genotypic distribution of human papillomavirus (HPV) and cervical cytology findings in 5906 Thai women undergoing cervical cancer screening programs

Nuttavut Kantathavorn, Chulabhorn Mahidol, Narongrit Sritana, Thaniya Sricharunrat, more

Infectious Agents and Cancer > 2015 > 10 > 1 > 1-9

Background Cervical cancer is the major cause of morbidity and mortality in Thai women. Nevertheless, the preventive strategy such as HPV vaccination program has not been implemented at the national level. This study explored the HPV prevalence and genotypic distribution in a large cohort of Thai women. Methods A hospital-based cervical cancer screening program at Chulabhorn Hospital,...

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The first case of human autochtonous subconjunctival dirofilariosis in Poland and MALT lymphoma as possible consequence of this parasitosis

Piotr K Borkowski, Grzegorz Rymkiewicz, Joanna Golebiewska, Nestor Nestoros, more

Infectious Agents and Cancer > 2015 > 10 > 1 > 1-5

The first case of human dirofilarosis in Poland was recorded in 2007. Until that time our country was free of Dirofilaria repens. Recent studies show that 21,4- 60% of dogs in Warsaw region harbour microfilariae, therefore it is becoming a growing problem in Central Europe. In April 2013 a subconjunctival D. repens was removed from the eye of 61-year-old woman. It was the twenty first case of this...

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Hepatocellular carcinoma and liver metastases: clinical data on a new dual-lumen catheter kit for surgical sealant infusion to prevent perihepatic bleeding and dissemination of cancer cells following biopsy and loco-regional treatments

Francesco Izzo, Raffaele Palaia, Vittorio Albino, Alfonso Amore, more

Infectious Agents and Cancer > 2015 > 10 > 1 > 1-7

Background RFA is a safe and effective procedure for treating unresectable primary or secondary liver malignancies, but it is not without complications. The most common reported complications include abdominal hemorrhage, bile leakage, biloma formation, hepatic abscesses, and neoplastic seeding. The aim of this study is to evaluate the feasibility of percutaneous use of surgical sealant with...

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Molecular screening for Epstein Barr virus (EBV) among Sudanese patients with nasopharyngeal carcinoma (NPC)

Hussain Gadelkarim Ahmed, Rania Saad Abdul Gader Suliman, Mohammed Siddig Abd El Aziz, Fawaz D Alshammari

Infectious Agents and Cancer > 2015 > 10 > 1 > 1-6

Objective The aim of this study was to screen for the presence of Epstein Barr Virus (EBV) among Sudanese patients with Nasopharyngeal Carcinoma (NPC). Methods In this study, 150 tissue samples that were previously diagnosed as having NPC were screened for the presence of EBV using Polymerase Chain Reaction (PCR). PCR was performed to amplify two viral genes; EBV nuclear antigen-4 (EBNA-4)...

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Prevalence of human cytomegalovirus, polyomaviruses, and oncogenic viruses in glioblastoma among Japanese subjects

Yumiko Hashida, Ayuko Taniguchi, Toshio Yawata, Sena Hosokawa, more

Infectious Agents and Cancer > 2015 > 10 > 1 > 1-9

Background The association between human cytomegalovirus (HCMV) and glioblastoma multiforme (GBM) is becoming a new concept. However, information on the geographic variability of HCMV prevalence in GBM remains scarce. Moreover, the potential roles of various viruses, such as polyomaviruses and oncogenic viruses, in gliomagenesis remain unclear. Our aim was to investigate the prevalence of HCMV...

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HIV and cancer: a comparative retrospective study of Brazilian and U.S. clinical cohorts

Jessica L Castilho, Paula M Luz, Bryan E Shepherd, Megan Turner, more

Infectious Agents and Cancer > 2015 > 10 > 1 > 1-10

Background With successful antiretroviral therapy, non-communicable diseases, including malignancies, are increasingly contributing to morbidity and mortality among HIV-infected persons. The epidemiology of AIDS-defining cancers (ADCs) and non-AIDS-defining cancers (NADCs) in HIV-infected populations in Brazil has not been well described. It is not known if cancer trends in HIV-infected populations...

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Expression of bcl-2 and p53 in bovine cutaneous fibropapillomas

Florentina Bocaneti, Gennaro Altamura, Annunziata Corteggio, Elena Velescu, more

Infectious Agents and Cancer > 2015 > 10 > 1 > 1-5

Background Bovine cutaneous fibropapillomas are benign hyperproliferative lesions induced by Bovine Papillomaviruses (BPVs). Bcl-2 is an important anti-apoptotic protein which is expressed in several cancer types. In contrary, p53 is a tumour suppressor protein that mediates cell cycle arrest, apoptosis and senescence in response to cellular stresses. Findings Here, we investigated immunohistochemically...

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Vaccines against human papillomavirus in low and middle income countries: a review of safety, immunogenicity and efficacy

Miriam Nakalembe, Florence M. Mirembe, Cecily Banura

Infectious Agents and Cancer > 2015 > 10 > 1 > 1-14

Currently, there is limited data on the immunogenicity and efficacy of human papillomavirus vaccines in Low and Middle income countries (LMIC). The review aims to summarize the current status from published HPV vaccine safety, immunogenicity and efficacy studies in low and middle income countries (LMIC). Electronic databases (PubMed/MEDLINE and HINARI) were searched for peer reviewed English language...

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A shifting paradigm in the aetiology of oral and pharyngeal cancer in Sri Lanka: a case-control study providing serologic evidence for the role of oncogenic HPV types 16 and 18

Suvanthee Kushani Gunasekera, Kanthi Angela Perera, Chandrika Fernando, Preethi Vidya Udagama

Infectious Agents and Cancer > 2015 > 10 > 1 > 1-9

Background Oral and pharyngeal cancer (OPC) of multifactorial aetiology is a major health problem globally. Ranking first in all cancers, OPC poses a significant impact on the Sri Lankan male population. As Human Papillomavirus (HPV) high risk (HR) types are found to be significant risk factors for OPC globally, the current study was undertaken to examine the association between HR-HPV16 and 18...

INFONA - science communication portal

Infectious Agents and Cancer

Epstein-Barr virus-specific methylation of human genes in gastric cancer cells

Disruption of Bcl-2 and Bcl-xL by viral proteins as a possible cause of cancer

The changing pattern of ano-rectal cancer, squamous cell carcinoma of the eye, and Hodgkin’s lymphoma as non-AIDS-defining cancers, by HIV status, in Tanzania over 11 years (2002-2012): a retrospective case-report study

Correlation of EGFR, pEGFR and p16 ^INK4 expressions and high risk HPV infection in HIV/AIDS-related squamous cell carcinoma of conjunctiva

Human Mammary Tumor Virus (HMTV) sequences in human milk

Detection of MMTV-Like sequences in Moroccan breast cancer cases

Risk factors for cervical HPV infection and genotypes distribution in HIV-infected South Brazilian women

HIV-1 Tat induces DNMT over-expression through microRNA dysregulation in HIV-related non Hodgkin lymphomas

Prevalence of HPV infection and other risk factors in a Fijian population

The GH-IGF-SST system in hepatocellular carcinoma: biological and molecular pathogenetic mechanisms and therapeutic targets

Prevalence and risk factors for High-Risk Human Papillomavirus (hrHPV) infection among HIV-infected and Uninfected Rwandan women: implications for hrHPV-based screening in Rwanda

Genotypic distribution of human papillomavirus (HPV) and cervical cytology findings in 5906 Thai women undergoing cervical cancer screening programs

The first case of human autochtonous subconjunctival dirofilariosis in Poland and MALT lymphoma as possible consequence of this parasitosis

Hepatocellular carcinoma and liver metastases: clinical data on a new dual-lumen catheter kit for surgical sealant infusion to prevent perihepatic bleeding and dissemination of cancer cells following biopsy and loco-regional treatments

Molecular screening for Epstein Barr virus (EBV) among Sudanese patients with nasopharyngeal carcinoma (NPC)

Prevalence of human cytomegalovirus, polyomaviruses, and oncogenic viruses in glioblastoma among Japanese subjects

HIV and cancer: a comparative retrospective study of Brazilian and U.S. clinical cohorts

Expression of bcl-2 and p53 in bovine cutaneous fibropapillomas

Vaccines against human papillomavirus in low and middle income countries: a review of safety, immunogenicity and efficacy

A shifting paradigm in the aetiology of oral and pharyngeal cancer in Sri Lanka: a case-control study providing serologic evidence for the role of oncogenic HPV types 16 and 18

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